Publications

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.

Nehme R, Pietilainen O, Artomov M, et al. The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia. Nat Commun. 2022;13(1):3690. doi:10.1038/s41467-022-31436-8.

Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis.

Dou Q, Turanov AA, Mariotti M, et al. Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis. J Biol Chem. 2022:102183. doi:10.1016/j.jbc.2022.102183.

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.

Chaffin M, Papangeli I, Simonson B, et al. Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy. Nature. 2022. doi:10.1038/s41586-022-04817-8.

Host protease activity classifies pneumonia etiology.

Anahtar M, Chan LW, Ko H, et al. Host protease activity classifies pneumonia etiology. Proc Natl Acad Sci U S A. 2022;119(25):e2121778119. doi:10.1073/pnas.2121778119.

Genome-wide mapping of somatic mutation rates uncovers drivers of cancer.

Sherman MA, Yaari AU, Priebe O, Dietlein F, Loh P-R, Berger B. Genome-wide mapping of somatic mutation rates uncovers drivers of cancer. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01353-8.

Granzyme K CD8 T cells form a core population in inflamed human tissue.

A Jonsson H, Zhang F, Dunlap G, et al. Granzyme K CD8 T cells form a core population in inflamed human tissue. Sci Transl Med. 2022;14(649):eabo0686. doi:10.1126/scitranslmed.abo0686.

Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.

Bustoros M, Anand S, Sklavenitis-Pistofidis R, et al. Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes. Nat Commun. 2022;13(1):3449. doi:10.1038/s41467-022-30694-w.

YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4.

Chen N, Golczer G, Ghose S, et al. YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4. Cell Rep. 2022;39(11):110970. doi:10.1016/j.celrep.2022.110970.

The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.

Hallacli E, Kayatekin C, Nazeen S, et al. The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability. Cell. 2022;185(12):2035-2056.e33. doi:10.1016/j.cell.2022.05.008.

RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.

Fang L, Ford-Roshon D, Russo M, et al. RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition. Nat Commun. 2022;13(1):3181. doi:10.1038/s41467-022-30794-7.