Publications

Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells.

Mouri K, Guo MH, de Boer CG, et al. Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells. Nat Genet. 2022. doi:10.1038/s41588-022-01056-5.

Improving polygenic prediction in ancestrally diverse populations.

Ruan Y, Lin Y-F, Feng Y-CAnne, et al. Improving polygenic prediction in ancestrally diverse populations. Nat Genet. 2022. doi:10.1038/s41588-022-01054-7.

Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease.

Kamath T, Abdulraouf A, Burris SJ, et al. Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease. Nat Neurosci. 2022;25(5):588-595. doi:10.1038/s41593-022-01061-1.

Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women.

Worby CJ, Schreiber HL, Straub TJ, et al. Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women. Nat Microbiol. 2022;7(5):630-639. doi:10.1038/s41564-022-01107-x.

Ancestry-inclusive dog genomics challenges popular breed stereotypes.

Morrill K, Hekman J, Li X, et al. Ancestry-inclusive dog genomics challenges popular breed stereotypes. Science. 2022;376(6592):eabk0639. doi:10.1126/science.abk0639.

Stepwise-edited, human melanoma models reveal mutations' effect on tumor and microenvironment.

Hodis E, Triglia ETorlai, Kwon JYH, et al. Stepwise-edited, human melanoma models reveal mutations' effect on tumor and microenvironment. Science. 2022;376(6592):eabi8175. doi:10.1126/science.abi8175.

Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset Of Resistance Mutations in Kinases.

Shekhar M, Smith Z, Seeliger M, Tiwary P. Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset Of Resistance Mutations in Kinases. Angew Chem Int Ed Engl. 2022. doi:10.1002/anie.202200983.

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control.

Gideon HP, Hughes TK, Tzouanas CN, et al. Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control. Immunity. 2022. doi:10.1016/j.immuni.2022.04.004.

High-Throughput Assay to Screen Small Molecules for Their Ability to Prevent Sickling of Red Blood Cells.

Nakagawa A, Cooper MK, Kost-Alimova M, et al. High-Throughput Assay to Screen Small Molecules for Their Ability to Prevent Sickling of Red Blood Cells. ACS Omega. 2022;7(16):14009-14016. doi:10.1021/acsomega.2c00541.

Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways.

Yu Z, Zekavat SM, Haidermota S, et al. Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways. Sci Adv. 2022;8(16):eabl4602. doi:10.1126/sciadv.abl4602.