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Nat Metab DOI:10.1038/s42255-021-00400-z

Human plasma proteomic profiles indicative of cardiorespiratory fitness.

Publication TypeJournal Article
Year of Publication2021
AuthorsRobbins, JM, Peterson, B, Schranner, D, Tahir, UA, Rienmüller, T, Deng, S, Keyes, MJ, Katz, DH, Beltran, PMJean, Barber, JL, Baumgartner, C, Carr, SA, Ghosh, S, Shen, C, Jennings, LL, Ross, R, Sarzynski, MA, Bouchard, C, Gerszten, RE
JournalNat Metab
Date Published2021 May 27
ISSN2522-5812
Abstract

Maximal oxygen uptake (VOmax) is a direct measure of human cardiorespiratory fitness and is associated with health. However, the molecular determinants of interindividual differences in baseline (intrinsic) VOmax, and of increases of VOmax in response to exercise training (ΔVOmax), are largely unknown. Here, we measure ~5,000 plasma proteins using an affinity-based platform in over 650 sedentary adults before and after a 20-week endurance-exercise intervention and identify 147 proteins and 102 proteins whose plasma levels are associated with baseline VOmax and ΔVOmax, respectively. Addition of a protein biomarker score derived from these proteins to a score based on clinical traits improves the prediction of an individual's ΔVOmax. We validate findings in a separate exercise cohort, further link 21 proteins to incident all-cause mortality in a community-based cohort and reproduce the specificity of ~75% of our key findings using antibody-based assays. Taken together, our data shed light on biological pathways relevant to cardiorespiratory fitness and highlight the potential additive value of protein biomarkers in identifying exercise responsiveness in humans.

DOI10.1038/s42255-021-00400-z
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/34045743?dopt=Abstract

Alternate JournalNat Metab
PubMed ID34045743
Grant ListU24 DK112340 / DK / NIDDK NIH HHS / United States
U24 DK112340 / DK / NIDDK NIH HHS / United States
U54 GM104940 / GM / NIGMS NIH HHS / United States
P30GM118430-01 / / U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) /
P30GM118430-01 / / U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) /
K23 HL150327-01A1 / / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) /
R01 HL146462 / HL / NHLBI NIH HHS / United States
R01 HL146462 / HL / NHLBI NIH HHS / United States
R01 HL132320 / HL / NHLBI NIH HHS / United States
R01 HL133870 / HL / NHLBI NIH HHS / United States