|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Ramaswamy, S, Golub, TR|
|Journal||Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology|
|Pages||1932 - 41|
|Keywords||Cancer, Gene Expression Profiling, Gene Expression Regulation, Humans, Neoplasms, Neoplastic, Oligonucleotide Array Sequence Analysis|
Aberrant gene expression is critical for tumor initiation and progression. However, we lack a comprehensive understanding of all genes that are aberrantly expressed in human cancer. Recently, DNA microarrays have been used to obtain global views of human cancer gene expression and to identify genetic markers that might be important for diagnosis and therapy. We review clinical applications of these novel tools, discuss some important recent studies, identify promising avenues of research in this emerging field of study, and discuss the likely impact that expression profiling will have on clinical oncology.