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Seminars in Hematology DOI:

MLL-rearranged leukemias: insights from gene expression profiling

Publication TypeJournal Article
Year of Publication2003
AuthorsArmstrong, SA, Golub, TR, Korsmeyer, SJ
JournalSeminars in Hematology
Pages268 - 73
Date Published2003/10//
ISBN Number0037-1963
KeywordsCancer, Cell Lineage, DNA-Binding Proteins, fms-Like Tyrosine Kinase 3, Gene Expression Profiling, Gene Rearrangement, Humans, Leukemia, Myeloid-Lymphoid Leukemia Protein, Proto-Oncogene Proteins, Proto-Oncogenes, Receptor Protein-Tyrosine Kinases, Transcription

Gene expression analysis of human leukemias has provided insight into disease classification and mechanisms of oncogenesis. Its success is particularly evident for acute leukemias with rearrangement of the mixed lineage leukemia (MLL) gene on chromosome 11q23. Unlike most other recurrent translocations, MLL rearrangements are found in leukemias classified as acute myelogenous leukemia (AML) or acute lymphoblastic leukemia (ALL). In addition, MLL-rearranged leukemias often express both myeloid- and lymphoid-associated genes. These unusual characteristics have generated much interest in the cell of origin and the mechanism of transformation by MLL rearrangements. Here we review insights gained from characterization of MLL-rearranged human leukemias by genome-wide expression profiling and compare these to data from model systems.