Bridging the gap between cancer cell line models and tumours using gene expression data.
Cancer cell line models are a cornerstone of cancer research, yet our understanding of how well they represent the molecular features of patient tumours remains limited. Our recent work provides a computational approach to systematically compare large gene expression datasets to better understand which cell lines most closely resemble each tumour type, as well as identify potential gaps in our current cancer models.
|Year of Publication||
Br J Cancer
2021 Mar 29