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Curr Opin Immunol DOI:10.1016/j.coi.2016.05.010

Genomic determinants of cancer immunotherapy.

Publication TypeJournal Article
Year of Publication2016
AuthorsMiao, D, Van Allen, EM
JournalCurr Opin Immunol
Date Published2016 Aug

Cancer immunotherapies - including therapeutic vaccines, adoptive cell transfer, oncolytic viruses, and immune checkpoint blockade - yield durable responses in many cancer types, but understanding of predictors of response is incomplete. Genomic characterization of human cancers has already contributed to the success of targeted therapies; in cancer immunotherapy, identification of tumor-specific antigens through whole-exome sequencing may be key to designing individualized, highly immunogenic therapeutic vaccines. Additionally, pre-treatment tumor mutational and gene expression signatures can predict which patients are most likely to benefit from cancer immunotherapy. Continued work in harnessing genomic, transcriptomic, and immunological data from clinical cohorts of immunotherapy-treated patients will bring the promises of precision medicine to immuno-oncology.


Alternate JournalCurr. Opin. Immunol.
PubMed ID27254251