Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.

Science
Authors
Keywords
Abstract

Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.

Year of Publication
2016
Journal
Science
Volume
352
Issue
6285
Pages
565-9
Date Published
2016 Apr 29
ISSN
1095-9203
URL
DOI
10.1126/science.aad3369
PubMed ID
27126040
PubMed Central ID
PMC5240844
Links
Grant list
P30 DK043351 / DK / NIDDK NIH HHS / United States