Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.
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Abstract | Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions. |
Year of Publication | 2016
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Journal | Science
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Volume | 352
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Issue | 6285
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Pages | 565-9
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Date Published | 2016 Apr 29
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ISSN | 1095-9203
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DOI | 10.1126/science.aad3369
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PubMed ID | 27126040
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PubMed Central ID | PMC5240844
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Grant list | P30 DK043351 / DK / NIDDK NIH HHS / United States
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