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Cancer Cell DOI:10.1016/j.ccell.2020.12.008

Targeting pan-essential genes in cancer: challenges and opportunities.

Publication TypeJournal Article
Year of Publication2021
AuthorsChang, L, Ruiz, P, Ito, T, Sellers, WR
JournalCancer Cell
Date Published2021 Jan 14

Despite remarkable successes in the clinic, cancer targeted therapy development remains challenging and the failure rate is disappointingly high. This problem is partly due to the misapplication of the targeted therapy paradigm to therapeutics targeting pan-essential genes, which can result in therapeutics whereby efficacy is attenuated by dose-limiting toxicity. Here we summarize the key features of successful chemotherapy and targeted therapy agents, and use case studies to outline recurrent challenges to drug development efforts targeting pan-essential genes. Finally, we suggest strategies to avoid previous pitfalls for ongoing and future development of pan-essential therapeutics.


Alternate JournalCancer Cell
PubMed ID33450197