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Cell Chem Biol DOI:10.1016/j.chembiol.2020.12.014

Nailing Down a Notoriously Elusive Cancer Target: Direct Inhibition of MYC by a Covalent Small Molecule.

Publication TypeJournal Article
Year of Publication2021
AuthorsHenley, MJ, Doyle, SK, Koehler, AN
JournalCell Chem Biol
Volume28
Issue1
Pages1-3
Date Published2021 Jan 21
ISSN2451-9448
Abstract

Direct inhibition of the transcription factor MYC is widely recognized as one of the thorniest challenges in cancer drug discovery. In this issue of Cell Chemical Biology, Boike et al. (2020) discover a covalent MYC inhibitor that selectively targets a single cysteine residue in an unstructured region of the protein.

DOI10.1016/j.chembiol.2020.12.014
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/33482085?dopt=Abstract

Alternate JournalCell Chem Biol
PubMed ID33482085