Nailing Down a Notoriously Elusive Cancer Target: Direct Inhibition of MYC by a Covalent Small Molecule.

Cell Chem Biol
Authors
Abstract

Direct inhibition of the transcription factor MYC is widely recognized as one of the thorniest challenges in cancer drug discovery. In this issue of Cell Chemical Biology, Boike et al. (2020) discover a covalent MYC inhibitor that selectively targets a single cysteine residue in an unstructured region of the protein.

Year of Publication
2021
Journal
Cell Chem Biol
Volume
28
Issue
1
Pages
1-3
Date Published
2021 Jan 21
ISSN
2451-9448
DOI
10.1016/j.chembiol.2020.12.014
PubMed ID
33482085
Links