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Cell DOI:10.1016/j.cell.2021.02.020

An expanded universe of cancer targets.

Publication TypeJournal Article
Year of Publication2021
AuthorsHahn, WC, Bader, JS, Braun, TP, Califano, A, Clemons, PA, Druker, BJ, Ewald, AJ, Fu, H, Jagu, S, Kemp, CJ, Kim, W, Kuo, CJ, McManus, M, Mills, GB, Mo, X, Sahni, N, Schreiber, SL, Talamas, JA, Tamayo, P, Tyner, JW, Wagner, BK, Weiss, WA, Gerhard, DS
Corporate AuthorsCancer Target Discovery and Development Network
Date Published2021 Mar 04

The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation.


Alternate JournalCell
PubMed ID33667368