Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.
Authors | |
Abstract | Immune responses differ between laboratory mice and humans. Chronic infection with viruses and parasites are common in humans, but are absent in laboratory mice, and thus represent potential contributors to inter-species differences in immunity. To test this, we sequentially infected laboratory mice with herpesviruses, influenza, and an intestinal helminth and compared their blood immune signatures to mock-infected mice before and after vaccination against yellow fever virus (YFV-17D). Sequential infection altered pre- and post-vaccination gene expression, cytokines, and antibodies in blood. Sequential pathogen exposure induced gene signatures that recapitulated those seen in blood from pet store-raised versus laboratory mice, and adult versus cord blood in humans. Therefore, basal and vaccine-induced murine immune responses are altered by infection with agents common outside of barrier facilities. This raises the possibility that we can improve mouse models of vaccination and immunity by selective microbial exposure of laboratory animals to mimic that of humans. |
Year of Publication | 2016
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Journal | Cell Host Microbe
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Volume | 19
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Issue | 5
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Pages | 713-9
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Date Published | 2016 May 11
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ISSN | 1934-6069
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URL | |
DOI | 10.1016/j.chom.2016.04.003
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PubMed ID | 27107939
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PubMed Central ID | PMC4896745
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Links | |
Grant list | R37 AI048638 / AI / NIAID NIH HHS / United States
R01 DK101354 / DK / NIDDK NIH HHS / United States
P30 CA077598 / CA / NCI NIH HHS / United States
U19 AI057266 / AI / NIAID NIH HHS / United States
R56 AI048638 / AI / NIAID NIH HHS / United States
R37 DK057665 / DK / NIDDK NIH HHS / United States
P30 AR048335 / AR / NIAMS NIH HHS / United States
R01 AI111918 / AI / NIAID NIH HHS / United States
R01 AI048638 / AI / NIAID NIH HHS / United States
R01 OD011170 / OD / NIH HHS / United States
R24 OD019793 / OD / NIH HHS / United States
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