Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.
Authors | |
Abstract | Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology. |
Year of Publication | 2016
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Journal | Nat Genet
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Volume | 48
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Issue | 5
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Pages | 552-5
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Date Published | 2016 May
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ISSN | 1546-1718
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URL | |
DOI | 10.1038/ng.3529
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PubMed ID | 26998691
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PubMed Central ID | PMC4986048
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Links | |
Grant list | K01 MH099286 / MH / NIMH NIH HHS / United States
102215 / Wellcome Trust / United Kingdom
MC_PC_15018 / Medical Research Council / United Kingdom
MC_UU_12013/1 / Medical Research Council / United Kingdom
MC_UU_12013/4 / Medical Research Council / United Kingdom
U01 MH094432 / MH / NIMH NIH HHS / United States
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