Gliomas Genomics and Epigenomics: Arriving at the Start and Knowing It for the First Time.

Annu Rev Pathol
Authors
Abstract

Gliomas are the most common primary human brain tumors and occur in both adults and children. Over the past few years, systematic large-scale genomic and epigenomic profiling has provided unprecedented insight into their pathogenesis, uncovering alterations in an unanticipated number of genes and regulatory elements. In this review, we discuss recent discoveries about the genomics and epigenomics of adult and pediatric gliomas and highlight how some of the founding genetic mutations reshape the cancer epigenome. These studies provide an in-depth view of the molecular routes leading to glioma development, offer insight into the cancer stem cell model, help refine classifications, and should lay the foundation for improved clinical care.

Year of Publication
2016
Journal
Annu Rev Pathol
Volume
11
Pages
497-521
Date Published
2016 May 23
ISSN
1553-4014
URL
DOI
10.1146/annurev-pathol-012615-044208
PubMed ID
26980161
Links