|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Spartano, NL, Himali, JJ, Beiser, AS, Lewis, GD, DeCarli, C, Vasan, RS, Seshadri, S|
|Date Published||2016 Apr 05|
|Keywords||Adult, Aged, Blood Pressure, Cerebrum, Exercise, Exercise Test, Female, Follow-Up Studies, Heart Rate, Humans, Male, Middle Aged, Physical Fitness|
OBJECTIVE: To determine whether poor cardiovascular (CV) fitness and exaggerated exercise blood pressure (BP) and heart rate (HR) were associated with worse brain morphology in later life.
METHODS: Framingham Offspring participants (n = 1,094, 53.9% female) free from dementia and CV disease (CVD) underwent an exercise treadmill test at a mean age of 40 ± 9 years. A second treadmill test and MRI scans of the brain were administered 2 decades later at mean age of 58 ± 8 years.
RESULTS: Poor CV fitness and greater diastolic BP and HR response to exercise at baseline were associated with a smaller total cerebral brain volume (TCBV) almost 2 decades later (all p
CONCLUSION: Our results suggest that lower CV fitness and exaggerated exercise BP and HR responses in middle-aged adults are associated with smaller brain volume nearly 2 decades later. Promotion of midlife CV fitness may be an important step towards ensuring healthy brain aging.
|PubMed Central ID||PMC4826343|
|Grant List||R01 NS017950 / NS / NINDS NIH HHS / United States |
R01 HL131029 / HL / NHLBI NIH HHS / United States
R01-AG008122 / AG / NIA NIH HHS / United States
R01 AG042292 / AG / NIA NIH HHS / United States
R01-NS017950 / NS / NINDS NIH HHS / United States
T32-HL07224 / HL / NHLBI NIH HHS / United States
R01-AG047645 / AG / NIA NIH HHS / United States
P30 AG010129 / AG / NIA NIH HHS / United States