Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

PLoS One
Authors
Keywords
Abstract

Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in ≈131K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P

Year of Publication
2018
Journal
PLoS One
Volume
13
Issue
6
Pages
e0198166
Date Published
2018
ISSN
1932-6203
DOI
10.1371/journal.pone.0198166
PubMed ID
29912962
PubMed Central ID
PMC6005576
Links
Grant list
P30 ES010126 / ES / NIEHS NIH HHS / United States
MR/K002414/1 / MRC_ / Medical Research Council / United Kingdom
U01 AG009740 / AG / NIA NIH HHS / United States
SP/13/2/30111 / BHF_ / British Heart Foundation / United Kingdom
G0700931 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12015/7 / MRC_ / Medical Research Council / United Kingdom
MC_UP_1605/7 / MRC_ / Medical Research Council / United Kingdom
MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom
G0601966 / MRC_ / Medical Research Council / United Kingdom
MC_PC_U127561128 / MRC_ / Medical Research Council / United Kingdom
R01 AG055406 / AG / NIA NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
R21 HL123677 / HL / NHLBI NIH HHS / United States
U01 AG023746 / AG / NIA NIH HHS / United States
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
R01 DK093757 / DK / NIDDK NIH HHS / United States
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
R01 DK117445 / DK / NIDDK NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
R01 HL118305 / HL / NHLBI NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
MC_UU_12015/5 / MRC_ / Medical Research Council / United Kingdom
R01 MD012765 / MD / NIMHD NIH HHS / United States
WT_ / Wellcome Trust / United Kingdom
P20 GM121334 / GM / NIGMS NIH HHS / United States
P01 CA196569 / CA / NCI NIH HHS / United States