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Biomaterials DOI:10.1016/j.biomaterials.2017.05.020

Mining for osteogenic surface topographies: In silico design to in vivo osseo-integration.

Publication TypeJournal Article
Year of Publication2017
AuthorsHulshof, FFB, Papenburg, B, Vasilevich, A, Hulsman, M, Zhao, Y, Levers, M, Fekete, N, de Boer, M, Yuan, H, Singh, S, Beijer, N, Bray, M-A, Logan, DJ, Reinders, M, Carpenter, AE, van Blitterswijk, C, Stamatialis, D, de Boer, J
JournalBiomaterials
Volume137
Pages49-60
Date Published2017 Aug
ISSN1878-5905
Abstract

Stem cells respond to the physicochemical parameters of the substrate on which they grow. Quantitative material activity relationships - the relationships between substrate parameters and the phenotypes they induce - have so far poorly predicted the success of bioactive implant surfaces. In this report, we screened a library of randomly selected designed surface topographies for those inducing osteogenic differentiation of bone marrow-derived mesenchymal stem cells. Cell shape features, surface design parameters, and osteogenic marker expression were strongly correlated in vitro. Furthermore, the surfaces with the highest osteogenic potential in vitro also demonstrated their osteogenic effect in vivo: these indeed strongly enhanced bone bonding in a rabbit femur model. Our work shows that by giving stem cells specific physicochemical parameters through designed surface topographies, differentiation of these cells can be dictated.

DOI10.1016/j.biomaterials.2017.05.020
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/28535442?dopt=Abstract

Alternate JournalBiomaterials
PubMed ID28535442