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Cell Host Microbe DOI:10.1016/j.chom.2015.11.008

Evolution and Spread of Ebola Virus in Liberia, 2014-2015.

Publication TypeJournal Article
Year of Publication2015
AuthorsLadner, JT, Wiley, MR, Mate, S, Dudas, G, Prieto, K, Lovett, S, Nagle, ER, Beitzel, B, Gilbert, ML, Fakoli, L, Diclaro, JW, Schoepp, RJ, Fair, J, Kuhn, JH, Hensley, LE, Park, DJ, Sabeti, PC, Rambaut, A, Sanchez-Lockhart, M, Bolay, FK, Kugelman, JR, Palacios, G
JournalCell Host Microbe
Volume18
Issue6
Pages659-69
Date Published2015 Dec 09
ISSN1934-6069
KeywordsCluster Analysis, Ebolavirus, Genetic Variation, Genome, Viral, Genotype, Hemorrhagic Fever, Ebola, Humans, Liberia, Molecular Epidemiology, Molecular Sequence Data, Phylogeography, Sequence Analysis, DNA, Sequence Homology
Abstract

The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1931-3128(15)00462-X
DOI10.1016/j.chom.2015.11.008
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/26651942?dopt=Abstract

Alternate JournalCell Host Microbe
PubMed ID26651942
PubMed Central IDPMC4711363
Grant List095831 / / Wellcome Trust / United Kingdom
HHSN272200700016I / AO / NIAID NIH HHS / United States
Z99 AI999999 / / Intramural NIH HHS / United States
HHSN272200700016I / / PHS HHS / United States