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Nat Commun DOI:10.1038/s41467-020-20585-3

Genetic determinants of daytime napping and effects on cardiometabolic health.

Publication TypeJournal Article
Year of Publication2021
AuthorsDashti, HS, Daghlas, I, Lane, JM, Huang, Y, Udler, MS, Wang, H, Ollila, HM, Jones, SE, Kim, J, Wood, AR, Weedon, MN, Aslibekyan, S, Garaulet, M, Saxena, R
Corporate Authors23andMe Research Team
JournalNat Commun
Volume12
Issue1
Pages900
Date Published2021 02 10
ISSN2041-1723
Abstract

Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide association study of self-reported daytime napping in the UK Biobank (n = 452,633) and identify 123 loci of which 61 replicate in the 23andMe research cohort (n = 541,333). Findings include missense variants in established drug targets for sleep disorders (HCRTR1, HCRTR2), genes with roles in arousal (TRPC6, PNOC), and genes suggesting an obesity-hypersomnolence pathway (PNOC, PATJ). Association signals are concordant with accelerometer-measured daytime inactivity duration and 33 loci colocalize with loci for other sleep phenotypes. Cluster analysis identifies three distinct clusters of nap-promoting mechanisms with heterogeneous associations with cardiometabolic outcomes. Mendelian randomization shows potential causal links between more frequent daytime napping and higher blood pressure and waist circumference.

DOI10.1038/s41467-020-20585-3
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/33568662?dopt=Abstract

Alternate JournalNat Commun
PubMed ID33568662
Grant ListR01 DK105072 / DK / NIDDK NIH HHS / United States
R01 DK107859 / DK / NIDDK NIH HHS / United States
F32 DK102323 / DK / NIDDK NIH HHS / United States
T32 HL007901 / HL / NHLBI NIH HHS / United States
R35 HL135818 / HL / NHLBI NIH HHS / United States
K23 DK114551 / DK / NIDDK NIH HHS / United States
MR/M005070/1 / MRC_ / Medical Research Council / United Kingdom