Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk.

Ann Neurol
Authors
Keywords
Abstract

The Genes and Environment in Multiple Sclerosis project establishes a platform to investigate the events leading to multiple sclerosis (MS) in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using an integrated genetic and environmental risk score, we identified subjects with twice the MS risk when compared to the average family member, and we report an initial incidence rate in these subjects that is 30 times greater than that of sporadic MS. We discuss the feasibility of large-scale studies of asymptomatic at-risk subjects that leverage modern tools of subject recruitment to execute collaborative projects.

Year of Publication
2016
Journal
Ann Neurol
Volume
79
Issue
2
Pages
178-89
Date Published
2016 Feb
ISSN
1531-8249
URL
DOI
10.1002/ana.24560
PubMed ID
26583565
PubMed Central ID
PMC4778957
Links
Grant list
K08 NS079493 / NS / NINDS NIH HHS / United States
K08-NS079493 / NS / NINDS NIH HHS / United States
Intramural NIH HHS / United States