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Trends Parasitol DOI:10.1016/

Comparative evolutionary genomics of human malaria parasites.

Publication TypeJournal Article
Year of Publication2008
AuthorsCarlton, JM, Escalante, AA, Neafsey, D, Volkman, SK
JournalTrends Parasitol
Date Published2008 Dec
KeywordsAnimals, Biological Evolution, Genome, Protozoan, Humans, Plasmodium falciparum, Plasmodium vivax

The parasites Plasmodium falciparum and Plasmodium vivax are responsible for the majority of human malaria cases worldwide. Despite many similarities in their biology, they frequently are studied in isolation. With the completion of the P. vivax genome and the generation of an initial P. falciparum genetic diversity map, attempts are being made to infer inter- and intra-species genome evolution. Here, we briefly review our current knowledge of comparative evolutionary genomics of the two species in the light of several presentations at the Molecular Approaches to Malaria 2008 meeting in Lorne, Australia and ask the question: can evolutionary genomics of one species inform the other?


Alternate JournalTrends Parasitol.
PubMed ID18938107
Grant ListR01 GM070793 / GM / NIGMS NIH HHS / United States
R01 GM080586 / GM / NIGMS NIH HHS / United States