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Nature DOI:10.1038/nature04332

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.

Publication TypeJournal Article
Year of Publication2005
AuthorsNierman, WC, Pain, A, Anderson, MJ, Wortman, JR, H Kim, S, Arroyo, J, Berriman, M, Abe, K, Archer, DB, Bermejo, C, Bennett, J, Bowyer, P, Chen, D, Collins, M, Coulsen, R, Davies, R, Dyer, PS, Farman, M, Fedorova, N, Fedorova, N, Feldblyum, TV, Fischer, R, Fosker, N, Fraser, A, García, JL, García, MJ, Goble, A, Goldman, GH, Gomi, K, Griffith-Jones, S, Gwilliam, R, Haas, B, Haas, H, Harris, D, Horiuchi, H, Huang, J, Humphray, S, Jiménez, J, Keller, N, Khouri, H, Kitamoto, K, Kobayashi, T, Konzack, S, Kulkarni, R, Kumagai, T, Lafon, A, Lafton, A, Latgé, J-P, Li, W, Lord, A, Lu, C, Majoros, WH, May, GS, Miller, BL, Mohamoud, Y, Molina, M, Monod, M, Mouyna, I, Mulligan, S, Murphy, L, O'Neil, S, Paulsen, I, Peñalva, MA, Pertea, M, Price, C, Pritchard, BL, Quail, MA, Rabbinowitsch, E, Rawlins, N, Rajandream, M-A, Reichard, U, Renauld, H, Robson, GD, de Córdoba, SRodriguez, Rodríguez-Peña, JM, Ronning, CM, Rutter, S, Salzberg, SL, Sanchez, M, Sánchez-Ferrero, JC, Saunders, D, Seeger, K, Squares, R, Squares, S, Takeuchi, M, Tekaia, F, Turner, G, de Aldana, CRVazquez, Weidman, J, White, O, Woodward, J, Yu, J-H, Fraser, C, Galagan, JE, Asai, K, Machida, M, Hall, N, Barrell, B, Denning, DW
JournalNature
Volume438
Issue7071
Pages1151-6
Date Published2005 Dec 22
ISSN1476-4687
KeywordsAllergens, Aspergillus fumigatus, Gene Expression Profiling, Gene Expression Regulation, Fungal, Genes, Fungal, Genome, Fungal, Genomics, Hypersensitivity, Molecular Sequence Data, Oligonucleotide Array Sequence Analysis, Sequence Analysis, DNA, Temperature, Virulence
Abstract

Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A. fumigatus is isolated from human habitats and vegetable compost heaps. In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref. 2). The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis. Although the burden of invasive disease caused by A. fumigatus is substantial, the basic biology of the organism is mostly obscure. Here we show the complete 29.4-megabase genome sequence of the clinical isolate Af293, which consists of eight chromosomes containing 9,926 predicted genes. Microarray analysis revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus.

URLhttp://dx.doi.org/10.1038/nature04332
DOI10.1038/nature04332
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/16372009?dopt=Abstract

Alternate JournalNature
PubMed ID16372009
Grant ListCFB17726 / / Biotechnology and Biological Sciences Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom