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Anaerobe DOI:10.1016/j.anaerobe.2015.10.013

Complete genome sequences and analysis of the Fusobacterium nucleatum subspecies animalis 7-1 bacteriophage ɸFunu1 and ɸFunu2.

Publication TypeJournal Article
Year of Publication2016
AuthorsCochrane, K, McGuire, AManson, Priest, ME, Abouelleil, A, Cerqueira, GC, Lo, R, Earl, AM, Allen-Vercoe, E
JournalAnaerobe
Volume38
Pages125-9
Date Published2016 Apr
ISSN1095-8274
KeywordsBacteriophages, Cluster Analysis, Computational Biology, DNA, Viral, Fusobacterium nucleatum, Genome, Viral, Genomics, Humans, Molecular Sequence Annotation, Sequence Analysis, DNA
Abstract

Fusobacterium nucleatum is a strictly anaerobic, Gram negative bacterial species that has been associated with dental infections, pre-term labor, appendicitis, inflammatory bowel disease, and, more recently, colorectal cancer. The species is unusual in its phenotypic and genotypic heterogeneity, with some strains demonstrating a more virulent phenotype than others; however, as yet the genetic basis for these differences is not understood. Bacteriophage are known to contribute to the virulence phenotype of several bacterial species. In this work, we set out to characterize the bacteriophage associated with F. nucleatum subsp. animalis strain 7-1, a highly invasive isolate from the human gastrointestinal tract. As well, we used computational approaches to predict and compare bacteriophage signatures across available sequenced F. nucleatum genomes.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1075-9964(15)30073-1
DOI10.1016/j.anaerobe.2015.10.013
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/26545740?dopt=Abstract

Alternate JournalAnaerobe
PubMed ID26545740
PubMed Central IDPMC4775352
Grant ListHHSN272200900018C / AI / NIAID NIH HHS / United States
U19 AI110818 / AI / NIAID NIH HHS / United States
HHSN272200900018C / / PHS HHS / United States
U19AI110818 / AI / NIAID NIH HHS / United States