Complete genome sequences and analysis of the Fusobacterium nucleatum subspecies animalis 7-1 bacteriophage ɸFunu1 and ɸFunu2.

Anaerobe
Authors
Keywords
Abstract

Fusobacterium nucleatum is a strictly anaerobic, Gram negative bacterial species that has been associated with dental infections, pre-term labor, appendicitis, inflammatory bowel disease, and, more recently, colorectal cancer. The species is unusual in its phenotypic and genotypic heterogeneity, with some strains demonstrating a more virulent phenotype than others; however, as yet the genetic basis for these differences is not understood. Bacteriophage are known to contribute to the virulence phenotype of several bacterial species. In this work, we set out to characterize the bacteriophage associated with F. nucleatum subsp. animalis strain 7-1, a highly invasive isolate from the human gastrointestinal tract. As well, we used computational approaches to predict and compare bacteriophage signatures across available sequenced F. nucleatum genomes.

Year of Publication
2016
Journal
Anaerobe
Volume
38
Pages
125-9
Date Published
2016 Apr
ISSN
1095-8274
URL
DOI
10.1016/j.anaerobe.2015.10.013
PubMed ID
26545740
PubMed Central ID
PMC4775352
Links
Grant list
HHSN272200900018C / AI / NIAID NIH HHS / United States
U19 AI110818 / AI / NIAID NIH HHS / United States
HHSN272200900018C / PHS HHS / United States
U19AI110818 / AI / NIAID NIH HHS / United States