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Cell Cycle DOI:10.1080/15384101.2015.1093712

A perspective on stem cell modeling of amyotrophic lateral sclerosis.

Publication TypeJournal Article
Year of Publication2015
AuthorsA de Boer, S, Eggan, K
JournalCell Cycle
Volume14
Issue23
Pages3679-88
Date Published2015
ISSN1551-4005
KeywordsAmyotrophic Lateral Sclerosis, Astrocytes, Cell Culture Techniques, Cell Differentiation, DNA-Binding Proteins, Humans, Induced Pluripotent Stem Cells, Microglia, RNA-Binding Protein FUS, Superoxide Dismutase, Superoxide Dismutase-1, Vesicular Transport Proteins
Abstract

Amyotrophic lateral sclerosis is a complex neurodegenerative disease. Limitations in animal models have impeded progress in studying disease pathology and potential drug discovery. Here, we will review recent advances in the development of stem cell models for the study of ALS. Additionally, we will discuss the progress toward therapeutic development derived from these stem cell based assays.

URLhttp://www.tandfonline.com/doi/full/10.1080/15384101.2015.1093712
DOI10.1080/15384101.2015.1093712
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/26505672?dopt=Abstract

Alternate JournalCell Cycle
PubMed ID26505672
PubMed Central IDPMC4825790
Grant ListR01NS089742 / NS / NINDS NIH HHS / United States
RC2NS069395 / NS / NINDS NIH HHS / United States
/ / Howard Hughes Medical Institute / United States