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Nature DOI:10.1038/s41586-020-2449-8

Perspectives on ENCODE.

Publication TypeJournal Article
Year of Publication2020
AuthorsSnyder, MP, Gingeras, TR, Moore, JE, Weng, Z, Gerstein, MB, Ren, B, Hardison, RC, Stamatoyannopoulos, JA, Graveley, BR, Feingold, EA, Pazin, MJ, Pagan, M, Gilchrist, DA, Hitz, BC, J Cherry, M, Bernstein, BE, Mendenhall, EM, Zerbino, DR, Frankish, A, Flicek, P, Myers, RM
Corporate AuthorsENCODE Project Consortium
JournalNature
Volume583
Issue7818
Pages693-698
Date Published2020 07
ISSN1476-4687
KeywordsAnimals, Binding Sites, Chromatin, Databases, Genetic, DNA Methylation, Gene Expression Regulation, Genome, Genome, Human, Genomics, Histones, Humans, Mice, Molecular Sequence Annotation, Quality Control, Regulatory Sequences, Nucleic Acid, Transcription Factors
Abstract

The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.

DOI10.1038/s41586-020-2449-8
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/32728248?dopt=Abstract

Alternate JournalNature
PubMed ID32728248
PubMed Central IDPMC7410827
Grant ListU41HG006993 / NH / NIH HHS / United States
U41HG006995 / NH / NIH HHS / United States
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U41HG007001 / NH / NIH HHS / United States
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R37 DK050107 / DK / NIDDK NIH HHS / United States
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U24 HG009397 / HG / NHGRI NIH HHS / United States
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U41HG006994 / NH / NIH HHS / United States
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U41HG006998 / NH / NIH HHS / United States
U01 HG007036 / HG / NHGRI NIH HHS / United States
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T32 GM087237 / GM / NIGMS NIH HHS / United States
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R01 DK068634 / DK / NIDDK NIH HHS / United States
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R01 GM083337 / GM / NIGMS NIH HHS / United States
U41HG006997 / NH / NIH HHS / United States