Perspectives on ENCODE.
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Abstract | The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community. |
Year of Publication | 2020
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Journal | Nature
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Volume | 583
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Issue | 7818
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Pages | 693-698
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Date Published | 2020 07
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ISSN | 1476-4687
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DOI | 10.1038/s41586-020-2449-8
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PubMed ID | 32728248
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PubMed Central ID | PMC7410827
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Links | |
Grant list | U41HG006993 / NH / NIH HHS / United States
U41HG006995 / NH / NIH HHS / United States
U41HG006996 / NH / NIH HHS / United States
U41HG007001 / NH / NIH HHS / United States
R01 DK050107 / DK / NIDDK NIH HHS / United States
U54 HG007004 / HG / NHGRI NIH HHS / United States
U01 HG007019 / HG / NHGRI NIH HHS / United States
U41HG007000 / NH / NIH HHS / United States
U01 HG007033 / HG / NHGRI NIH HHS / United States
U54 HG007010 / HG / NHGRI NIH HHS / United States
R37 DK050107 / DK / NIDDK NIH HHS / United States
U41HG007003 / NH / NIH HHS / United States
U41 HG006992 / HG / NHGRI NIH HHS / United States
U41 HG007234 / HG / NHGRI NIH HHS / United States
U54 HG007005 / HG / NHGRI NIH HHS / United States
U24 HG009397 / HG / NHGRI NIH HHS / United States
U54 HG006998 / HG / NHGRI NIH HHS / United States
U41HG006994 / NH / NIH HHS / United States
U54 HG006991 / HG / NHGRI NIH HHS / United States
U41HG006998 / NH / NIH HHS / United States
U01 HG007036 / HG / NHGRI NIH HHS / United States
U41HG007002 / NH / NIH HHS / United States
U41HG006999 / NH / NIH HHS / United States
T32 GM087237 / GM / NIGMS NIH HHS / United States
U01 HG007037 / HG / NHGRI NIH HHS / United States
R01 DK068634 / DK / NIDDK NIH HHS / United States
UM1 HG009442 / HG / NHGRI NIH HHS / United States
U54 HG006997 / HG / NHGRI NIH HHS / United States
R01 GM083337 / GM / NIGMS NIH HHS / United States
U41HG006997 / NH / NIH HHS / United States
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