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Cell Stem Cell DOI:10.1016/j.stem.2015.08.013

Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders.

Publication TypeJournal Article
Year of Publication2015
AuthorsHyman, SE
JournalCell Stem Cell
Volume17
Issue3
Pages253-4
Date Published2015 Sep 03
ISSN1875-9777
KeywordsCell Adhesion Molecules, Neuronal, Humans, Mental Disorders, Models, Biological, Mutation, Nerve Tissue Proteins, Synaptic Transmission
Abstract

Connecting rare genetic variants to neuropsychiatric disease mechanisms remains a significant challenge. In this issue of Cell Stem Cell, Pak et al. (2015) combine gene targeting and stem cell technologies to identify a significant cellular effect of rare penetrant NRXN1 mutations in human neurons, which was found to cause a defect in neurotransmitter release.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1934-5909(15)00368-9
DOI10.1016/j.stem.2015.08.013
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/26340523?dopt=Abstract

Alternate JournalCell Stem Cell
PubMed ID26340523