Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Pelleau, S, Moss, EL, Dhingra, SK, Volney, B, Casteras, J, Gabryszewski, SJ, Volkman, SK, Wirth, DF, Legrand, E, Fidock, DA, Neafsey, DE, Musset, L |
Journal | Proc Natl Acad Sci U S A |
Volume | 112 |
Issue | 37 |
Pages | 11672-7 |
Date Published | 2015 Sep 15 |
ISSN | 1091-6490 |
Keywords | Alleles, Chloroquine, Drug Resistance, Evolution, Molecular, French Guiana, Genetic Markers, Genome, Genotype, Haplotypes, Humans, Inhibitory Concentration 50, Malaria, Membrane Transport Proteins, Mutation, Phenotype, Plasmodium falciparum, Prevalence, Principal Component Analysis, Protozoan Proteins, Quinolines, Retrospective Studies |
Abstract | In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line treatment of Plasmodium falciparum infections has typically led to the restoration of CQ susceptibility through the reexpansion of the wild-type (WT) allele K76 of the chloroquine resistance transporter gene (pfcrt) at the expense of less fit mutant alleles carrying the CQ resistance (CQR) marker K76T. In low-transmission settings, such as South America, drug resistance mutations can attain 100% prevalence, thereby precluding the return of WT parasites after the complete removal of drug pressure. In French Guiana, despite the fixation of the K76T allele, the prevalence of CQR isolates progressively dropped from >90% to |
URL | http://www.pnas.org/cgi/pmidlookup?view=long&pmid=26261345 |
DOI | 10.1073/pnas.1507142112 |
Pubmed | |
Alternate Journal | Proc. Natl. Acad. Sci. U.S.A. |
PubMed ID | 26261345 |
PubMed Central ID | PMC4577156 |
Grant List | HHSN272200900018C / AI / NIAID NIH HHS / United States R01 AI050234 / AI / NIAID NIH HHS / United States F30 AI114070 / AI / NIAID NIH HHS / United States T32 GM007367 / GM / NIGMS NIH HHS / United States R01 AI109023 / AI / NIAID NIH HHS / United States HHSN272200900018C / / PHS HHS / United States R01AI50234 / AI / NIAID NIH HHS / United States R01AI109023 / AI / NIAID NIH HHS / United States |
Proc Natl Acad Sci U S A DOI:10.1073/pnas.1507142112
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.
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