Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Ma, S, Yim, SHee, Lee, S-G, Kim, EBae, Lee, S-R, Chang, K-T, Buffenstein, R, Lewis, KN, Park, TJ, Miller, RA, Clish, CB, Gladyshev, VN |
Journal | Cell Metab |
Volume | 22 |
Issue | 2 |
Pages | 332-43 |
Date Published | 2015 Aug 04 |
ISSN | 1932-7420 |
Keywords | Animals, Brain, Kidney, Liver, Longevity, Mammals, Metabolome, Mice, Myocardium, Organ Specificity, Species Specificity |
Abstract | Biological diversity among mammals is remarkable. Mammalian body weights range seven orders of magnitude and lifespans differ more than 100-fold among species. While genetic, dietary, and pharmacological interventions can be used to modulate these traits in model organisms, it is unknown how they are determined by natural selection. By profiling metabolites in brain, heart, kidney, and liver tissues of 26 mammalian species representing ten taxonomical orders, we report metabolite patterns characteristic of organs, lineages, and species longevity. Our data suggest different rates of metabolite divergence across organs and reveal patterns representing organ-specific functions and lineage-specific physiologies. We identified metabolites that correlated with species lifespan, some of which were previously implicated in longevity control. We also compared the results with metabolite changes in five long-lived mouse models and observed some similar patterns. Overall, this study describes adjustments of the mammalian metabolome according to lifespan, phylogeny, and organ and lineage specialization. |
URL | http://linkinghub.elsevier.com/retrieve/pii/S1550-4131(15)00334-4 |
DOI | 10.1016/j.cmet.2015.07.005 |
Pubmed | |
Alternate Journal | Cell Metab. |
PubMed ID | 26244935 |
PubMed Central ID | PMC4758382 |
Grant List | GM109312 / GM / NIGMS NIH HHS / United States AG047745 / AG / NIA NIH HHS / United States R01 AG019899 / AG / NIA NIH HHS / United States U19 AG023122 / AG / NIA NIH HHS / United States P01 AG047200 / AG / NIA NIH HHS / United States K01 GM109312 / GM / NIGMS NIH HHS / United States U01 AG022303 / AG / NIA NIH HHS / United States P30 AG024824 / AG / NIA NIH HHS / United States R01 AG021518 / AG / NIA NIH HHS / United States AG047200 / AG / NIA NIH HHS / United States DP1 AG047745 / AG / NIA NIH HHS / United States AG021518 / AG / NIA NIH HHS / United States P01 AG031736 / AG / NIA NIH HHS / United States |
Cell Metab DOI:10.1016/j.cmet.2015.07.005
Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.
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