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Cell Metab DOI:10.1016/j.cmet.2015.07.005

Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.

Publication TypeJournal Article
Year of Publication2015
AuthorsMa, S, Yim, SHee, Lee, S-G, Kim, EBae, Lee, S-R, Chang, K-T, Buffenstein, R, Lewis, KN, Park, TJ, Miller, RA, Clish, CB, Gladyshev, VN
JournalCell Metab
Volume22
Issue2
Pages332-43
Date Published2015 Aug 04
ISSN1932-7420
KeywordsAnimals, Brain, Kidney, Liver, Longevity, Mammals, Metabolome, Mice, Myocardium, Organ Specificity, Species Specificity
Abstract

Biological diversity among mammals is remarkable. Mammalian body weights range seven orders of magnitude and lifespans differ more than 100-fold among species. While genetic, dietary, and pharmacological interventions can be used to modulate these traits in model organisms, it is unknown how they are determined by natural selection. By profiling metabolites in brain, heart, kidney, and liver tissues of 26 mammalian species representing ten taxonomical orders, we report metabolite patterns characteristic of organs, lineages, and species longevity. Our data suggest different rates of metabolite divergence across organs and reveal patterns representing organ-specific functions and lineage-specific physiologies. We identified metabolites that correlated with species lifespan, some of which were previously implicated in longevity control. We also compared the results with metabolite changes in five long-lived mouse models and observed some similar patterns. Overall, this study describes adjustments of the mammalian metabolome according to lifespan, phylogeny, and organ and lineage specialization.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1550-4131(15)00334-4
DOI10.1016/j.cmet.2015.07.005
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/26244935?dopt=Abstract

Alternate JournalCell Metab.
PubMed ID26244935
PubMed Central IDPMC4758382
Grant ListGM109312 / GM / NIGMS NIH HHS / United States
AG047745 / AG / NIA NIH HHS / United States
R01 AG019899 / AG / NIA NIH HHS / United States
U19 AG023122 / AG / NIA NIH HHS / United States
P01 AG047200 / AG / NIA NIH HHS / United States
K01 GM109312 / GM / NIGMS NIH HHS / United States
U01 AG022303 / AG / NIA NIH HHS / United States
P30 AG024824 / AG / NIA NIH HHS / United States
R01 AG021518 / AG / NIA NIH HHS / United States
AG047200 / AG / NIA NIH HHS / United States
DP1 AG047745 / AG / NIA NIH HHS / United States
AG021518 / AG / NIA NIH HHS / United States
P01 AG031736 / AG / NIA NIH HHS / United States