From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.

Cell Stem Cell

Authors	John McNeish Jason Gardner Brian Wainger Clifford Woolf Kevin Eggan
Keywords	Animals Humans Mice Mutation Induced Pluripotent Stem Cells Carbamates Amyotrophic Lateral Sclerosis Superoxide Dismutase Drug Discovery Phenylenediamines Clinical Trials as Topic Models, Neurological Translational Medical Research Motor Neurons Superoxide Dismutase-1
Abstract	While iPSCs have created unprecedented opportunities for drug discovery, there remains uncertainty concerning the path to the clinic for candidate therapeutics discovered with their use. Here we share lessons that we learned, and believe are generalizable to similar efforts, while taking a discovery made using iPSCs into a clinical trial.
Year of Publication	2015
Journal	Cell Stem Cell
Volume	17
Issue	1
Pages	8-10
Date Published	2015 Jul 02
ISSN	1875-9777
URL	http://linkinghub.elsevier.com/retrieve/pii/S1934-5909(15)00273-8
DOI	10.1016/j.stem.2015.06.013
PubMed ID	26140603
Links	DOI PubMed Google Scholar
Grant list	R01 NS038253 / NS / NINDS NIH HHS / United States Howard Hughes Medical Institute / United States