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Science DOI:10.1126/science.abe3261

Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.

Publication TypeJournal Article
Year of Publication2020
AuthorsLemieux, JE, Siddle, KJ, Shaw, BM, Loreth, C, Schaffner, SF, Gladden-Young, A, Adams, G, Fink, T, Tomkins-Tinch, CH, Krasilnikova, LA, DeRuff, KC, Rudy, M, Bauer, MR, Lagerborg, KA, Normandin, E, Chapman, SB, Reilly, SK, Anahtar, MN, Lin, AE, Carter, A, Myhrvold, C, Kemball, ME, Chaluvadi, S, Cusick, C, Flowers, K, Neumann, A, Cerrato, F, Farhat, M, Slater, D, Harris, JB, Branda, JA, Hooper, D, Gaeta, JM, Baggett, TP, O'Connell, J, Gnirke, A, Lieberman, TD, Philippakis, A, Burns, M, Brown, CM, Luban, J, Ryan, ET, Turbett, SE, LaRocque, RC, Hanage, WP, Gallagher, GR, Madoff, LC, Smole, S, Pierce, VM, Rosenberg, E, Sabeti, PC, Park, DJ, MacInnis, BL
JournalScience
Date Published2020 Dec 10
ISSN1095-9203
Abstract

Analysis of 772 complete SARS-CoV-2 genomes from early in the Boston area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two superspreading events. One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, while other introductions into the facility had little effect. The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread. The two events also differed significantly in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events. Our results show how genomic epidemiology can help understand the link between individual clusters and wider community spread.

DOI10.1126/science.abe3261
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/33303686?dopt=Abstract

Alternate JournalScience
PubMed ID33303686