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Nature DOI:10.1038/s41586-020-2876-6

A comparative genomics multitool for scientific discovery and conservation.

Publication TypeJournal Article
Year of Publication2020
Corporate AuthorsZoonomia Consortium
JournalNature
Volume587
Issue7833
Pages240-245
Date Published2020 11
ISSN1476-4687
Abstract

The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.

DOI10.1038/s41586-020-2876-6
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/33177664?dopt=Abstract

Alternate JournalNature
PubMed ID33177664
Grant ListR01 HG008742 / HG / NHGRI NIH HHS / United States
R01 HG002939 / HG / NHGRI NIH HHS / United States
5U24HG010136 / NH / NIH HHS / United States
5R01HG010485 / NH / NIH HHS / United States
2U41HG007234 / NH / NIH HHS / United States
5P01AG047200 / NH / NIH HHS / United States
1UH2AG064706 / NH / NIH HHS / United States
200517/Z/16/Z / WT_ / Wellcome Trust / United Kingdom
Additional Materials