Web-based phenotyping for Tourette Syndrome: Reliability of common co-morbid diagnoses.

Psychiatry Res
Authors
Keywords
Abstract

Collecting phenotypic data necessary for genetic analyses of neuropsychiatric disorders is time consuming and costly. Development of web-based phenotype assessments would greatly improve the efficiency and cost-effectiveness of genetic research. However, evaluating the reliability of this approach compared to standard, in-depth clinical interviews is essential. The current study replicates and extends a preliminary report on the utility of a web-based screen for Tourette Syndrome (TS) and common comorbid diagnoses (obsessive compulsive disorder (OCD) and attention deficit/hyperactivity disorder (ADHD)). A subset of individuals who completed a web-based phenotyping assessment for a TS genetic study was invited to participate in semi-structured diagnostic clinical interviews. The data from these interviews were used to determine participants' diagnostic status for TS, OCD, and ADHD using best estimate procedures, which then served as the gold standard to compare diagnoses assigned using web-based screen data. The results show high rates of agreement for TS. Kappas for OCD and ADHD diagnoses were also high and together demonstrate the utility of this self-report data in comparison previous diagnoses from clinicians and dimensional assessment methods.

Year of Publication
2015
Journal
Psychiatry Res
Volume
228
Issue
3
Pages
816-25
Date Published
2015 Aug 30
ISSN
1872-7123
URL
DOI
10.1016/j.psychres.2015.05.017
PubMed ID
26054936
PubMed Central ID
PMC4532555
Links
Grant list
K23MH085057 / MH / NIMH NIH HHS / United States
K02MH00508 / MH / NIMH NIH HHS / United States
K23 MH085057 / MH / NIMH NIH HHS / United States
Z01 MH000508 / MH / NIMH NIH HHS / United States
R01NS016648 / NS / NINDS NIH HHS / United States
U01 NS040024 / NS / NINDS NIH HHS / United States
R01 MH096767 / MH / NIMH NIH HHS / United States
R01 NS016648 / NS / NINDS NIH HHS / United States
U01NS040024 / NS / NINDS NIH HHS / United States
R01MH096767 / MH / NIMH NIH HHS / United States