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Biol Psychiatry DOI:10.1016/j.biopsych.2015.04.020

Learning From Animal Models of Obsessive-Compulsive Disorder.

Publication TypeJournal Article
Year of Publication2016
AuthorsMonteiro, P, Feng, G
JournalBiol Psychiatry
Volume79
Issue1
Pages7-16
Date Published2016 Jan 01
ISSN1873-2402
KeywordsAnimals, Brain, Disease Models, Animal, Humans, Obsessive-Compulsive Disorder
Abstract

Obsessive-compulsive disorder (OCD) affects 2%-3% of the population worldwide and can cause significant distress and disability. Substantial challenges remain in the field of OCD research and therapeutics. Approved interventions alleviate symptoms only partially, with 30%-40% of patients being resistant to treatment. Although the etiology of OCD is still unknown, research evidence points toward the involvement of cortico-striato-thalamocortical circuitry. This review focuses on the most recent behavioral, genetics, and neurophysiologic findings from animal models of OCD. Based on evidence from these models and parallels with human studies, we discuss the circuit hyperactivity hypothesis for OCD, a potential circuitry dysfunction of action termination, and the involvement of candidate genes. Adding a more biologically valid framework to OCD will help researchers define and test new hypotheses and facilitate the development of targeted therapies based on disease-specific mechanisms.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S0006-3223(15)00358-3
DOI10.1016/j.biopsych.2015.04.020
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/26037910?dopt=Abstract

Alternate JournalBiol. Psychiatry
PubMed ID26037910
PubMed Central IDPMC4633402
Grant ListR01 MH081201 / MH / NIMH NIH HHS / United States
R01 MH097104 / MH / NIMH NIH HHS / United States