BFC: correcting Illumina sequencing errors.

Bioinformatics

Authors	Heng Li
Keywords	Humans Computational Biology Algorithms Reproducibility of Results Software High-Throughput Nucleotide Sequencing Sequence Analysis, DNA Genome, Human False Positive Reactions
Abstract	UNLABELLED: BFC is a free, fast and easy-to-use sequencing error corrector designed for Illumina short reads. It uses a non-greedy algorithm but still maintains a speed comparable to implementations based on greedy methods. In evaluations on real data, BFC appears to correct more errors with fewer overcorrections in comparison to existing tools. It particularly does well in suppressing systematic sequencing errors, which helps to improve the base accuracy of de novo assemblies. AVAILABILITY AND IMPLEMENTATION: https://github.com/lh3/bfc CONTACT: hengli@broadinstitute.org SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Year of Publication	2015
Journal	Bioinformatics
Volume	31
Issue	17
Pages	2885-7
Date Published	2015 Sep 01
ISSN	1367-4811
URL	http://bioinformatics.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=25953801
DOI	10.1093/bioinformatics/btv290
PubMed ID	25953801
PubMed Central ID	PMC4635656
Links	Google Scholar PubMed DOI
Grant list	GM100233 / GM / NIGMS NIH HHS / United States U54HG003037 / HG / NHGRI NIH HHS / United States

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