Sequencing and beyond: integrating molecular 'omics' for microbial community profiling.
Authors | |
Keywords | |
Abstract | High-throughput DNA sequencing has proven invaluable for investigating diverse environmental and host-associated microbial communities. In this Review, we discuss emerging strategies for microbial community analysis that complement and expand traditional metagenomic profiling. These include novel DNA sequencing strategies for identifying strain-level microbial variation and community temporal dynamics; measuring multiple 'omic' data types that better capture community functional activity, such as transcriptomics, proteomics and metabolomics; and combining multiple forms of omic data in an integrated framework. We highlight studies in which the 'multi-omics' approach has led to improved mechanistic models of microbial community structure and function. |
Year of Publication | 2015
|
Journal | Nat Rev Microbiol
|
Volume | 13
|
Issue | 6
|
Pages | 360-72
|
Date Published | 2015 Jun
|
ISSN | 1740-1534
|
URL | |
DOI | 10.1038/nrmicro3451
|
PubMed ID | 25915636
|
PubMed Central ID | PMC4800835
|
Links | |
Grant list | R01 HG005969 / HG / NHGRI NIH HHS / United States
U54 DK102557 / DK / NIDDK NIH HHS / United States
R01HG005969 / HG / NHGRI NIH HHS / United States
U54DK102557 / DK / NIDDK NIH HHS / United States
|