Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.

Nat Commun
Authors
Keywords
Abstract

Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis in 15,369 cases and 19,517 controls of Caucasian and Chinese ancestries. We identify four novel associations at LOC144817, COG6, RUNX1 and TP63, as well as three novel secondary associations within IFIH1 and IL12B. Fine-mapping analysis of MHC region demonstrates an important role for all three HLA class I genes and a complex and heterogeneous pattern of HLA associations between Caucasian and Chinese populations. Further, trans-ethnic comparison suggests population-specific effect or allelic heterogeneity for 11 loci. These population-specific effects contribute significantly to the ethnic diversity of psoriasis prevalence. This study not only provides novel biological insights into the involvement of immune and keratinocyte development mechanism, but also demonstrates a complex and heterogeneous genetic architecture of psoriasis susceptibility across ethnic populations.

Year of Publication
2015
Journal
Nat Commun
Volume
6
Pages
6916
Date Published
2015 Apr 23
ISSN
2041-1723
URL
DOI
10.1038/ncomms7916
PubMed ID
25903422
PubMed Central ID
PMC4423213
Links
Grant list
R01 AR050266 / AR / NIAMS NIH HHS / United States
R01AR065174 / AR / NIAMS NIH HHS / United States
R01AR050266 / AR / NIAMS NIH HHS / United States
R01 AR065174 / AR / NIAMS NIH HHS / United States
K08 AR057763 / AR / NIAMS NIH HHS / United States
K08AR057763 / AR / NIAMS NIH HHS / United States