Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.

Nat Genet
Authors
Keywords
Abstract

Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine mapped the MHC association signal to identify additional risk factors independent of the HLA-DQA1 and HLA-DQB1 alleles and observed five new associations that account for 18% of the genetic risk. Taking these new loci together with the 57 known non-MHC loci, genetic variation can now explain up to 48% of celiac disease heritability.

Year of Publication
2015
Journal
Nat Genet
Volume
47
Issue
6
Pages
577-8
Date Published
2015 Jun
ISSN
1546-1718
URL
DOI
10.1038/ng.3268
PubMed ID
25894500
PubMed Central ID
PMC4449296
Links
Grant list
1R01AR062886 / AR / NIAMS NIH HHS / United States
U01 GM092691 / GM / NIGMS NIH HHS / United States
322698 / European Research Council / International
R01 AR063759 / AR / NIAMS NIH HHS / United States
R01 AR062886 / AR / NIAMS NIH HHS / United States
UH2 AR067677 / AR / NIAMS NIH HHS / United States