Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.

Nat Genet

Authors	Javier Gutierrez-Achury Alexandra Zhernakova Sara Pulit Gosia Trynka Karen Hunt Jihane Romanos Soumya Raychaudhuri David van Heel Cisca Wijmenga Paul de Bakker
Keywords	Humans Genetic Predisposition to Disease Haplotypes Chromosome Mapping Risk Factors Case-Control Studies Genetic Association Studies Risk Celiac Disease HLA-DQ alpha-Chains HLA-DQ beta-Chains
Abstract	Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine mapped the MHC association signal to identify additional risk factors independent of the HLA-DQA1 and HLA-DQB1 alleles and observed five new associations that account for 18% of the genetic risk. Taking these new loci together with the 57 known non-MHC loci, genetic variation can now explain up to 48% of celiac disease heritability.
Year of Publication	2015
Journal	Nat Genet
Volume	47
Issue	6
Pages	577-8
Date Published	2015 Jun
ISSN	1546-1718
URL	http://dx.doi.org/10.1038/ng.3268
DOI	10.1038/ng.3268
PubMed ID	25894500
PubMed Central ID	PMC4449296
Links	PubMed DOI Google Scholar
Grant list	1R01AR062886 / AR / NIAMS NIH HHS / United States U01 GM092691 / GM / NIGMS NIH HHS / United States 322698 / European Research Council / International R01 AR063759 / AR / NIAMS NIH HHS / United States R01 AR062886 / AR / NIAMS NIH HHS / United States UH2 AR067677 / AR / NIAMS NIH HHS / United States

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