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Nat Commun DOI:10.1038/ncomms7791

Distinct metabolomic signatures are associated with longevity in humans.

Publication TypeJournal Article
Year of Publication2015
AuthorsCheng, S, Larson, MG, McCabe, EL, Murabito, JM, Rhee, EP, Ho, JE, Jacques, PF, Ghorbani, A, Magnusson, M, Souza, AL, Deik, AA, Pierce, KA, Bullock, K, O'Donnell, CJ, Melander, O, Clish, CB, Vasan, RS, Gerszten, RE, Wang, TJ
JournalNat Commun
Volume6
Pages6791
Date Published2015 Apr 13
ISSN2041-1723
KeywordsAged, Aged, 80 and over, Biomarkers, Cardiovascular Diseases, Chromatography, Liquid, Female, Humans, Isocitrates, Longevity, Longitudinal Studies, Male, Mass Spectrometry, Metabolome, Middle Aged, Neoplasms, Odds Ratio, Prognosis, Survival Analysis, Taurocholic Acid
Abstract

Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, taurocholate, are associated with lower odds of longevity, defined as attaining 80 years of age. Higher concentrations of isocitrate, but not taurocholate, are also associated with worse cardiovascular health at baseline, as well as risk of future cardiovascular disease and death. None of the metabolites identified are associated with cancer risk. Our findings suggest that some, but not all, metabolic pathways related to human longevity are linked to the risk of common causes of death.

URLhttp://dx.doi.org/10.1038/ncomms7791
DOI10.1038/ncomms7791
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25864806?dopt=Abstract

Alternate JournalNat Commun
PubMed ID25864806
PubMed Central IDPMC4396657
Grant ListN01-HC-25195 / HC / NHLBI NIH HHS / United States
K23-HL-116780 / HL / NHLBI NIH HHS / United States
R00-HL-107642 / HL / NHLBI NIH HHS / United States
R01 DK081572 / DK / NIDDK NIH HHS / United States
R01-HL-098280 / HL / NHLBI NIH HHS / United States
R01 HL098280 / HL / NHLBI NIH HHS / United States
R01-AG-29451 / AG / NIA NIH HHS / United States
R01 HL081572 / HL / NHLBI NIH HHS / United States
K08-DK-090142 / DK / NIDDK NIH HHS / United States
R00 HL107642 / HL / NHLBI NIH HHS / United States
R01-DK-HL-081572 / DK / NIDDK NIH HHS / United States
K08 DK090142 / DK / NIDDK NIH HHS / United States
K23 HL116780 / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
U01-HL-107440 / HL / NHLBI NIH HHS / United States
U01 HL107440 / HL / NHLBI NIH HHS / United States
K99 HL107642 / HL / NHLBI NIH HHS / United States