Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development.
Am J Hum Genet
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Abstract | Human height is a composite measurement, reflecting the sum of leg, spine, and head lengths. Many common variants influence total height, but the effects of these or other variants on the components of height (body proportion) remain largely unknown. We studied sitting height ratio (SHR), the ratio of sitting height to total height, to identify such effects in 3,545 African Americans and 21,590 individuals of European ancestry. We found that SHR is heritable: 26% and 39% of the total variance of SHR can be explained by common variants in European and African Americans, respectively, and global European admixture is negatively correlated with SHR in African Americans (r(2) ≈ 0.03). Six regions reached genome-wide significance (p |
Year of Publication | 2015
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Journal | Am J Hum Genet
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Volume | 96
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Issue | 5
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Pages | 695-708
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Date Published | 2015 May 07
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ISSN | 1537-6605
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URL | |
DOI | 10.1016/j.ajhg.2015.02.018
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PubMed ID | 25865494
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PubMed Central ID | PMC4570286
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Grant list | G1001799 / Medical Research Council / United Kingdom
K99 HL122515 / HL / NHLBI NIH HHS / United States
R01DK075787 / DK / NIDDK NIH HHS / United States
1K99HL122515-01A1 / HL / NHLBI NIH HHS / United States
R01 DK075787 / DK / NIDDK NIH HHS / United States
MR/N01104X/1 / Medical Research Council / United Kingdom
MC_PC_15018 / Medical Research Council / United Kingdom
MC_UU_12013/1 / Medical Research Council / United Kingdom
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