A novel Alzheimer disease locus located near the gene encoding tau protein.
Mol Psychiatry
Authors | |
Keywords | |
Abstract | APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ɛ4+ (10 352 cases and 9207 controls) and APOE ɛ4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE ɛ4 status. Suggestive associations (P |
Year of Publication | 2016
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Journal | Mol Psychiatry
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Volume | 21
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Issue | 1
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Pages | 108-17
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Date Published | 2016 Jan
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ISSN | 1476-5578
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URL | |
DOI | 10.1038/mp.2015.23
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PubMed ID | 25778476
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PubMed Central ID | PMC4573764
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Grant list | P30 AG013854 / AG / NIA NIH HHS / United States
N01HC55020 / HL / NHLBI NIH HHS / United States
P50 MH060451 / MH / NIMH NIH HHS / United States
N01HC55222 / HC / NHLBI NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
U01-HG004402 / HG / NHGRI NIH HHS / United States
K01 AG030514 / AG / NIA NIH HHS / United States
AG033040 / AG / NIA NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
MR/K013041/1 / Medical Research Council / United Kingdom
RC2 HL102419 / HL / NHLBI NIH HHS / United States
R01 HL103612 / HL / NHLBI NIH HHS / United States
MC_U123192748 / Medical Research Council / United Kingdom
P30 AG010124 / AG / NIA NIH HHS / United States
P50 AG023501 / AG / NIA NIH HHS / United States
RC2-HL102419 / HL / NHLBI NIH HHS / United States
089701 / Wellcome Trust / United Kingdom
R01 AG17917 / AG / NIA NIH HHS / United States
U01 HG006375 / HG / NHGRI NIH HHS / United States
UL1TR000124 / TR / NCATS NIH HHS / United States
UC2 HL103010 / HL / NHLBI NIH HHS / United States
R01 NS017950 / NS / NINDS NIH HHS / United States
M01 RR000096 / RR / NCRR NIH HHS / United States
RC2 AG036528 / AG / NIA NIH HHS / United States
N01AG12100 / AG / NIA NIH HHS / United States
P30 AG028377 / AG / NIA NIH HHS / United States
RF1 AG015819 / AG / NIA NIH HHS / United States
P50 AG008671 / AG / NIA NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
R01AG15928 / AG / NIA NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
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R01 AG016495 / AG / NIA NIH HHS / United States
U01 AG10483 / AG / NIA NIH HHS / United States
P30 AG10133 / AG / NIA NIH HHS / United States
N01HC85080 / HC / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
P50 AG005131 / AG / NIA NIH HHS / United States
R01 AG015928 / AG / NIA NIH HHS / United States
P50 AG005128 / AG / NIA NIH HHS / United States
P30 AG010133 / AG / NIA NIH HHS / United States
U24 AG021886 / AG / NIA NIH HHS / United States
R01 AG031581 / AG / NIA NIH HHS / United States
K24HL038444 / HL / NHLBI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
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P50 AG005146 / AG / NIA NIH HHS / United States
MR/L501529/1 / Medical Research Council / United Kingdom
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MC_U123160651 / Medical Research Council / United Kingdom
N01-HC-55022 / HC / NHLBI NIH HHS / United States
R01 AG019085 / AG / NIA NIH HHS / United States
U01 AG032984 / AG / NIA NIH HHS / United States
167 / Alzheimer's Society / United Kingdom
R01 AG030146 / AG / NIA NIH HHS / United States
HHSN268200800007C / HL / NHLBI NIH HHS / United States
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089703 / Wellcome Trust / United Kingdom
MR/L501517/1 / Medical Research Council / United Kingdom
R01 HL105756 / HL / NHLBI NIH HHS / United States
AG041718 / AG / NIA NIH HHS / United States
AG08122 / AG / NIA NIH HHS / United States
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R01-HL093029 / HL / NHLBI NIH HHS / United States
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Howard Hughes Medical Institute / United States
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N01HC55019 / HL / NHLBI NIH HHS / United States
R01HL087652 / HL / NHLBI NIH HHS / United States
N01HC85082 / HL / NHLBI NIH HHS / United States
MR/K006584/1 / Medical Research Council / United Kingdom
R01AG033193 / AG / NIA NIH HHS / United States
R01 AG030653 / AG / NIA NIH HHS / United States
N01HC85083 / HL / NHLBI NIH HHS / United States
R01 AG027944 / AG / NIA NIH HHS / United States
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UL1RR02777 / RR / NCRR NIH HHS / United States
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R01HL120393 / HL / NHLBI NIH HHS / United States
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