A novel Alzheimer disease locus located near the gene encoding tau protein.

Mol Psychiatry
Authors
Keywords
Abstract

APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ɛ4+ (10 352 cases and 9207 controls) and APOE ɛ4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE ɛ4 status. Suggestive associations (P

Year of Publication
2016
Journal
Mol Psychiatry
Volume
21
Issue
1
Pages
108-17
Date Published
2016 Jan
ISSN
1476-5578
URL
DOI
10.1038/mp.2015.23
PubMed ID
25778476
PubMed Central ID
PMC4573764
Links
Grant list
P30 AG013854 / AG / NIA NIH HHS / United States
N01HC55020 / HL / NHLBI NIH HHS / United States
P50 MH060451 / MH / NIMH NIH HHS / United States
N01HC55222 / HC / NHLBI NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
U01-HG004402 / HG / NHGRI NIH HHS / United States
K01 AG030514 / AG / NIA NIH HHS / United States
AG033040 / AG / NIA NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
MR/K013041/1 / Medical Research Council / United Kingdom
RC2 HL102419 / HL / NHLBI NIH HHS / United States
R01 HL103612 / HL / NHLBI NIH HHS / United States
MC_U123192748 / Medical Research Council / United Kingdom
P30 AG010124 / AG / NIA NIH HHS / United States
P50 AG023501 / AG / NIA NIH HHS / United States
RC2-HL102419 / HL / NHLBI NIH HHS / United States
089701 / Wellcome Trust / United Kingdom
R01 AG17917 / AG / NIA NIH HHS / United States
U01 HG006375 / HG / NHGRI NIH HHS / United States
UL1TR000124 / TR / NCATS NIH HHS / United States
UC2 HL103010 / HL / NHLBI NIH HHS / United States
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167 / Alzheimer's Society / United Kingdom
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089703 / Wellcome Trust / United Kingdom
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Howard Hughes Medical Institute / United States
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R01HL087652 / HL / NHLBI NIH HHS / United States
N01HC85082 / HL / NHLBI NIH HHS / United States
MR/K006584/1 / Medical Research Council / United Kingdom
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R01 AG030653 / AG / NIA NIH HHS / United States
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