Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

PLoS Genet
Authors
Keywords
Abstract

Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies. These analyses identified nine loci with eleven independent variants which reached genome-wide significance (P

Year of Publication
2017
Journal
PLoS Genet
Volume
13
Issue
5
Pages
e1006728
Date Published
2017 May
ISSN
1553-7404
DOI
10.1371/journal.pgen.1006728
PubMed ID
28498854
PubMed Central ID
PMC5446189
Links
Grant list
U01 HG007417 / HG / NHGRI NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
R01 HL128782 / HL / NHLBI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
R01 DK094907 / DK / NIDDK NIH HHS / United States
R21 HL123677 / HL / NHLBI NIH HHS / United States
S10 OD020069 / OD / NIH HHS / United States
R21 HL121429 / HL / NHLBI NIH HHS / United States
R01 HL055673 / HL / NHLBI NIH HHS / United States