Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

PLoS Genet
Publication type
Journal Article
Authors
Jingjing Liang
Thu Le
Digna Edwards
Bamidele Tayo
Kyle Gaulton
Jennifer Smith
Yingchang Lu
Richard Jensen
Guanjie Chen
Lisa Yanek
Karen Schwander
Salman Tajuddin
Tamar Sofer
Wonji Kim
James Kayima
Colin McKenzie
Ervin Fox
Michael Nalls
J Hunter Young
Yan Sun
Jacqueline Lane
Sylvia Cechova
Jie Zhou
Hua Tang
Myriam Fornage
Solomon Musani
Heming Wang
Juyoung Lee
Adebowale Adeyemo
Albert Dreisbach
Terrence Forrester
Pei-Lun Chu
Anne Cappola
Michele Evans
Alanna Morrison
Lisa Martin
Kerri Wiggins
Qin Hui
Wei Zhao
Rebecca Jackson
Erin Ware
Jessica Faul
Alex Reiner
Michael Bray
Joshua Denny
Thomas Mosley
Walter Palmas
Xiuqing Guo
George Papanicolaou
Alan Penman
Joseph Polak
Kenneth Rice
Ken Taylor
Eric Boerwinkle
Erwin Bottinger
Kiang Liu
Neil Risch
Steven Hunt
Charles Kooperberg
Alan Zonderman
Cathy Laurie
Diane Becker
Jianwen Cai
Ruth Loos
Bruce Psaty
David Weir
Sharon Kardia
Donna Arnett
Sungho Won
Todd Edwards
Susan Redline
Richard Cooper
D Rao
Jerome Rotter
Charles Rotimi
Daniel Levy
Aravinda Chakravarti
Xiaofeng Zhu
Nora Franceschini
Keywords
Animals
Female
Humans
Male
Mice
Basic Helix-Loop-Helix Transcription Factors
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Case-Control Studies
Membrane Proteins
Multifactorial Inheritance
Genetic Loci
Cadherins
Blood Pressure
Hypertension
African Americans
Abstract

Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies. These analyses identified nine loci with eleven independent variants which reached genome-wide significance (P

Year of Publication
2017
Journal
PLoS Genet
Volume
13
Issue
5
Pages
e1006728
Date Published
2017 May
ISSN
1553-7404
DOI
10.1371/journal.pgen.1006728
PubMed ID
28498854
PubMed Central ID
PMC5446189
Links
Grant list
U01 HG007417 / HG / NHGRI NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
R01 HL128782 / HL / NHLBI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
R01 DK094907 / DK / NIDDK NIH HHS / United States
R21 HL123677 / HL / NHLBI NIH HHS / United States
S10 OD020069 / OD / NIH HHS / United States
R21 HL121429 / HL / NHLBI NIH HHS / United States
R01 HL055673 / HL / NHLBI NIH HHS / United States

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