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J Am Soc Nephrol DOI:10.1681/ASN.2012101006

A combined epidemiologic and metabolomic approach improves CKD prediction.

Publication TypeJournal Article
Year of Publication2013
AuthorsRhee, EP, Clish, CB, Ghorbani, A, Larson, MG, Elmariah, S, McCabe, E, Yang, Q, Cheng, S, Pierce, K, Deik, A, Souza, AL, Farrell, L, Domos, C, Yeh, RW, Palacios, I, Rosenfield, K, Vasan, RS, Florez, JC, Wang, TJ, Fox, CS, Gerszten, RE
JournalJ Am Soc Nephrol
Date Published2013 Jul
KeywordsAged, Biomarkers, Chromatography, Liquid, Female, Follow-Up Studies, Humans, Incidence, Kidney Failure, Chronic, Kidney Function Tests, Male, Mass Spectrometry, Metabolomics, Middle Aged, Prospective Studies, Risk Factors

Metabolomic approaches have begun to catalog the metabolic disturbances that accompany CKD, but whether metabolite alterations can predict future CKD is unknown. We performed liquid chromatography/mass spectrometry-based metabolite profiling on plasma from 1434 participants in the Framingham Heart Study (FHS) who did not have CKD at baseline. During the following 8 years, 123 individuals developed CKD, defined by an estimated GFR of


Alternate JournalJ. Am. Soc. Nephrol.
PubMed ID23687356
PubMed Central IDPMC3736702
Grant ListN01-HC-25195 / HC / NHLBI NIH HHS / United States
R01-DK-HL081572 / DK / NIDDK NIH HHS / United States
R01 HL081572 / HL / NHLBI NIH HHS / United States
K08-DK-090142 / DK / NIDDK NIH HHS / United States
K08 DK090142 / DK / NIDDK NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States