New genetic loci link adipose and insulin biology to body fat distribution.

Nature
Authors
Keywords
Abstract

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P 

Year of Publication
2015
Journal
Nature
Volume
518
Issue
7538
Pages
187-96
Date Published
2015 Feb 12
ISSN
1476-4687
URL
DOI
10.1038/nature14132
PubMed ID
25673412
PubMed Central ID
PMC4338562
Links
Grant list
R01 DK093757 / DK / NIDDK NIH HHS / United States
MC_UU_12012/1 / Medical Research Council / United Kingdom
CZB/4/710 / Chief Scientist Office / United Kingdom
G9521010 / Medical Research Council / United Kingdom
G1001799 / Medical Research Council / United Kingdom
K23 DK080145 / DK / NIDDK NIH HHS / United States
098017 / Wellcome Trust / United Kingdom
G0601463 / Medical Research Council / United Kingdom
R21 DA027040 / DA / NIDA NIH HHS / United States
RG/13/2/30098 / British Heart Foundation / United Kingdom
P30 DK040561 / DK / NIDDK NIH HHS / United States
U01 HG007419 / HG / NHGRI NIH HHS / United States
RG/08/008/25291 / British Heart Foundation / United Kingdom
R01 HL109946 / HL / NHLBI NIH HHS / United States
MC_UP_A100_1003 / Medical Research Council / United Kingdom
12/0004470 / Diabetes UK / United Kingdom
085235 / Wellcome Trust / United Kingdom
U01 HG007416 / HG / NHGRI NIH HHS / United States
T32 GM067553 / GM / NIGMS NIH HHS / United States
RG/08/014/24067 / British Heart Foundation / United Kingdom
R01 DK072193 / DK / NIDDK NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
MC_UU_12019/1 / Medical Research Council / United Kingdom
G1000143 / Medical Research Council / United Kingdom
U01 HG007376 / HG / NHGRI NIH HHS / United States
Z01 HG000024-14 / Intramural NIH HHS / United States
R01 DK075787 / DK / NIDDK NIH HHS / United States
MR/L003120/1 / Medical Research Council / United Kingdom
R01 AG025941 / AG / NIA NIH HHS / United States
R01 AG041517 / AG / NIA NIH HHS / United States
MC_UU_12015/1 / Medical Research Council / United Kingdom
R01 DK062370 / DK / NIDDK NIH HHS / United States
R01 DK107437 / DK / NIDDK NIH HHS / United States
MC_UP_A620_1014 / Medical Research Council / United Kingdom
MC_U106179471 / Medical Research Council / United Kingdom
MR/N01104X/1 / Medical Research Council / United Kingdom
097117 / Wellcome Trust / United Kingdom
MC_UU_12015/2 / Medical Research Council / United Kingdom
098498 / Wellcome Trust / United Kingdom
P20 MD006899 / MD / NIMHD NIH HHS / United States
P30 DK072488 / DK / NIDDK NIH HHS / United States
K01 HL116770 / HL / NHLBI NIH HHS / United States
14136 / Cancer Research UK / United Kingdom
MC_U106179472 / Medical Research Council / United Kingdom
R01 AG033193 / AG / NIA NIH HHS / United States
G0401527 / Medical Research Council / United Kingdom
MC_UU_12013/1 / Medical Research Council / United Kingdom
R00 HL094535 / HL / NHLBI NIH HHS / United States
P30 DK020541 / DK / NIDDK NIH HHS / United States
MC_PC_U127561128 / Medical Research Council / United Kingdom
UM1 CA182913 / CA / NCI NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
T32 GM007092 / GM / NIGMS NIH HHS / United States
084766 / Wellcome Trust / United Kingdom
100574 / Wellcome Trust / United Kingdom
P30 GM103341 / GM / NIGMS NIH HHS / United States
R01 DK089256 / DK / NIDDK NIH HHS / United States
FS/14/55/30806 / British Heart Foundation / United Kingdom
MR/K006584/1 / Medical Research Council / United Kingdom
MR/K013351/1 / Medical Research Council / United Kingdom
MC_UU_12011/1 / Medical Research Council / United Kingdom
T32 HL069768 / HL / NHLBI NIH HHS / United States
P30 DK020572 / DK / NIDDK NIH HHS / United States
MC_UU_12015/5 / Medical Research Council / United Kingdom
P60 DK020541 / DK / NIDDK NIH HHS / United States
R01 HL117626 / HL / NHLBI NIH HHS / United States
098381 / Wellcome Trust / United Kingdom
R01 HL117078 / HL / NHLBI NIH HHS / United States
MR/K011480/1 / Medical Research Council / United Kingdom
UM1 CA182910 / CA / NCI NIH HHS / United States
T32 HL007055 / HL / NHLBI NIH HHS / United States
G0601261 / Medical Research Council / United Kingdom
R01 DK078150 / DK / NIDDK NIH HHS / United States
RG/10/12/28456 / British Heart Foundation / United Kingdom
U01 AG049505 / AG / NIA NIH HHS / United States