Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

Nat Genet
Authors
Anubha Mahajan
Jennifer Wessel
Sara Willems
Wei Zhao
Neil Robertson
Audrey Chu
Wei Gan
Hidetoshi Kitajima
Daniel Taliun
N William Rayner
Xiuqing Guo
Yingchang Lu
Man Li
Richard Jensen
Yao Hu
Shaofeng Huo
Kurt Lohman
Weihua Zhang
James Cook
Bram Prins
Jason Flannick
Niels Grarup
Vassily Trubetskoy
Jasmina Kravic
Young Kim
Denis Rybin
Hanieh Yaghootkar
Martina Müller-Nurasyid
Karina Meidtner
Ruifang Li-Gao
Tibor Varga
Jonathan Marten
Jin Li
Albert Smith
Ping An
Symen Ligthart
Stefan Gustafsson
Giovanni Malerba
Ayse Demirkan
Juan Tajes
Valgerdur Steinthorsdottir
Matthias Wuttke
Cecile Lecoeur
Michael Preuss
Lawrence Bielak
Marielisa Graff
Heather Highland
Anne Justice
Dajiang Liu
Eirini Marouli
Gina Peloso
Helen Warren
ExomeBP Consortium
MAGIC Consortium
GIANT Consortium
Saima Afaq
Shoaib Afzal
Emma Ahlqvist
Peter Almgren
Najaf Amin
Lia Bang
Alain Bertoni
Cristina Bombieri
Jette Bork-Jensen
Ivan Brandslund
Jennifer Brody
Noel Burtt
Mickaël Canouil
Yii-Der Chen
Yoon Cho
Cramer Christensen
Sophie Eastwood
Kai-Uwe Eckardt
Krista Fischer
Giovanni Gambaro
Vilmantas Giedraitis
Megan Grove
Hugoline de Haan
Sophie Hackinger
Yang Hai
Sohee Han
Anne Tybjærg-Hansen
Marie-France Hivert
Bo Isomaa
Susanne Jäger
Marit Jørgensen
Torben Jørgensen
AnneMari Käräjämäki
Bong-Jo Kim
Sung Kim
Heikki Koistinen
Peter Kovacs
Jennifer Kriebel
Florian Kronenberg
Kristi Läll
Leslie Lange
Jung-Jin Lee
Benjamin Lehne
Huaixing Li
Keng-Hung Lin
Allan Linneberg
Ching-Ti Liu
Jun Liu
Marie Loh
Reedik Mägi
Vasiliki Mamakou
Roberta McKean-Cowdin
Girish Nadkarni
Matt Neville
Sune Nielsen
Ioanna Ntalla
Patricia Peyser
Wolfgang Rathmann
Kenneth Rice
Stephen Rich
Line Rode
Olov Rolandsson
Sebastian Schönherr
Elizabeth Selvin
Kerrin Small
Alena Stančáková
Praveen Surendran
Kent Taylor
Tanya Teslovich
Barbara Thorand
Gudmar Thorleifsson
Adrienne Tin
Anke Tönjes
Anette Varbo
Daniel Witte
Andrew Wood
Pranav Yajnik
Jie Yao
Loic Yengo
Robin Young
Philippe Amouyel
Heiner Boeing
Eric Boerwinkle
Erwin Bottinger
Rajiv Chowdhury
Francis Collins
George Dedoussis
Abbas Dehghan
Panos Deloukas
Marco Ferrario
Jean Ferrières
Jose Florez
Philippe Frossard
Vilmundur Gudnason
Tamara Harris
Susan Heckbert
Joanna Howson
Martin Ingelsson
Sekar Kathiresan
Frank Kee
Johanna Kuusisto
Claudia Langenberg
Lenore Launer
Cecilia Lindgren
Satu Männistö
Thomas Meitinger
Olle Melander
Karen Mohlke
Marie Moitry
Andrew Morris
Alison Murray
Renée de Mutsert
Marju Orho-Melander
Katharine Owen
Markus Perola
Annette Peters
Michael Province
Asif Rasheed
Paul Ridker
Fernando Rivadineira
Frits Rosendaal
Anders Rosengren
Veikko Salomaa
Wayne Sheu
Rob Sladek
Blair Smith
Konstantin Strauch
André Uitterlinden
Rohit Varma
Cristen Willer
Matthias Blüher
Adam Butterworth
John Chambers
Daniel Chasman
John Danesh
Cornelia van Duijn
Josée Dupuis
Oscar Franco
Paul Franks
Philippe Froguel
Harald Grallert
Leif Groop
Bok-Ghee Han
Torben Hansen
Andrew Hattersley
Caroline Hayward
Erik Ingelsson
Sharon Kardia
Fredrik Karpe
Jaspal Kooner
Anna Köttgen
Kari Kuulasmaa
Markku Laakso
Xu Lin
Lars Lind
Yongmei Liu
Ruth Loos
Jonathan Marchini
Andres Metspalu
Dennis Mook-Kanamori
Børge Nordestgaard
Colin Palmer
James Pankow
Oluf Pedersen
Bruce Psaty
Rainer Rauramaa
Naveed Sattar
Matthias Schulze
Nicole Soranzo
Timothy Spector
Kari Stefansson
Michael Stumvoll
Unnur Thorsteinsdottir
Tiinamaija Tuomi
Jaakko Tuomilehto
Nicholas Wareham
James Wilson
Eleftheria Zeggini
Robert Scott
Inês Barroso
Timothy Frayling
Mark Goodarzi
James Meigs
Michael Boehnke
Danish Saleheen
Andrew Morris
Jerome Rotter
Mark McCarthy
Keywords
Female
Humans
Male
Genetic Predisposition to Disease
Alleles
Chromosome Mapping
Genome-Wide Association Study
Genetic Variation
European Continental Ancestry Group
Diabetes Mellitus, Type 2
Whole Exome Sequencing
Abstract

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P 

Year of Publication
2018
Journal
Nat Genet
Volume
50
Issue
4
Pages
559-571
Date Published
2018 04
ISSN
1546-1718
DOI
10.1038/s41588-018-0084-1
PubMed ID
29632382
PubMed Central ID
PMC5898373
Links
Grant list
G0601463 / MRC_ / Medical Research Council / United Kingdom
RG/13/13/30194 / BHF_ / British Heart Foundation / United Kingdom
U01 DK085545 / DK / NIDDK NIH HHS / United States
R01 DK098032 / DK / NIDDK NIH HHS / United States
R35 HL135824 / HL / NHLBI NIH HHS / United States
MR/L003120/1 / MRC_ / Medical Research Council / United Kingdom
P30 DK063491 / DK / NIDDK NIH HHS / United States
K24 DK080140 / DK / NIDDK NIH HHS / United States
U01 DK078616 / DK / NIDDK NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
P30 DK116074 / DK / NIDDK NIH HHS / United States
U54 GM115428 / GM / NIGMS NIH HHS / United States
R01 DK093757 / DK / NIDDK NIH HHS / United States
R01 DK078616 / DK / NIDDK NIH HHS / United States
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
U01 HL130114 / HL / NHLBI NIH HHS / United States
MR/K023241/1 / MRC_ / Medical Research Council / United Kingdom
MR/L020149/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK072193 / DK / NIDDK NIH HHS / United States
R00 HL130580 / HL / NHLBI NIH HHS / United States
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
R01 HL119443 / HL / NHLBI NIH HHS / United States
R01 DK062370 / DK / NIDDK NIH HHS / United States
U01 DK105535 / DK / NIDDK NIH HHS / United States
MR/S003746/1 / MRC_ / Medical Research Council / United Kingdom
MC_PC_U127561128 / MRC_ / Medical Research Council / United Kingdom
P30 DK020572 / DK / NIDDK NIH HHS / United States
RG/14/5/30893 / BHF_ / British Heart Foundation / United Kingdom
MR/K007017/1 / MRC_ / Medical Research Council / United Kingdom
P20 GM121334 / GM / NIGMS NIH HHS / United States
MC_PC_13040 / MRC_ / Medical Research Council / United Kingdom
UL1 TR001881 / TR / NCATS NIH HHS / United States
T32 HL007055 / HL / NHLBI NIH HHS / United States
G0601261 / MRC_ / Medical Research Council / United Kingdom

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