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Cell Host Microbe DOI:10.1016/j.chom.2015.01.001

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.

Publication TypeJournal Article
Year of Publication2015
AuthorsKostic, AD, Gevers, D, Siljander, H, Vatanen, T, Hyötyläinen, T, Hämäläinen, A-M, Peet, A, Tillmann, V, Pöhö, P, Mattila, I, Lähdesmäki, H, Franzosa, EA, Vaarala, O, de Goffau, M, Harmsen, H, Ilonen, J, Virtanen, SM, Clish, CB, Orešič, M, Huttenhower, C, Knip, M, Xavier, RJ
Corporate AuthorsDIABIMMUNE Study Group
JournalCell Host Microbe
Volume17
Issue2
Pages260-73
Date Published2015 Feb 11
ISSN1934-6069
KeywordsCohort Studies, Diabetes Mellitus, Type 1, Gastrointestinal Microbiome, Gastrointestinal Tract, Humans, Infant
Abstract

Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1 diabetes (T1D), we examined a cohort of 33 infants genetically predisposed to T1D. Modeling trajectories of microbial abundances through infancy revealed a subset of microbial relationships shared across most subjects. Although strain composition of a given species was highly variable between individuals, it was stable within individuals throughout infancy. Metabolic composition and metabolic pathway abundance remained constant across time. A marked drop in alpha-diversity was observed in T1D progressors in the time window between seroconversion and T1D diagnosis, accompanied by spikes in inflammation-favoring organisms, gene functions, and serum and stool metabolites. This work identifies trends in the development of the human infant gut microbiome along with specific alterations that precede T1D onset and distinguish T1D progressors from nonprogressors.

URLhttp://linkinghub.elsevier.com/retrieve/pii/S1931-3128(15)00021-9
DOI10.1016/j.chom.2015.01.001
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25662751?dopt=Abstract

Alternate JournalCell Host Microbe
PubMed ID25662751
PubMed Central IDPMC4689191
Grant ListP30 DK043351 / DK / NIDDK NIH HHS / United States
U54 DK102557 / DK / NIDDK NIH HHS / United States