Nutrient-sensing mechanisms and pathways.

Nature
Authors
Keywords
Abstract

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels of sugars, amino acids, lipids and surrogate metabolites are integrated and coordinated at the organismal level through hormonal signals. During food abundance, nutrient-sensing pathways engage anabolism and storage, whereas scarcity triggers homeostatic mechanisms, such as the mobilization of internal stores through autophagy. Nutrient-sensing pathways are commonly deregulated in human metabolic diseases.

Year of Publication
2015
Journal
Nature
Volume
517
Issue
7534
Pages
302-10
Date Published
2015 Jan 15
ISSN
1476-4687
URL
DOI
10.1038/nature14190
PubMed ID
25592535
PubMed Central ID
PMC4313349
Links
Grant list
R01 AI047389 / AI / NIAID NIH HHS / United States
R01 CA103866 / CA / NCI NIH HHS / United States
AI047389 / AI / NIAID NIH HHS / United States
CA103866 / CA / NCI NIH HHS / United States
R37 AI047389 / AI / NIAID NIH HHS / United States
R21 AG042876 / AG / NIA NIH HHS / United States
Howard Hughes Medical Institute / United States
R01 CA129105 / CA / NCI NIH HHS / United States