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Science DOI:10.1126/science.1258522

Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.

Publication TypeJournal Article
Year of Publication2015
AuthorsNeafsey, DE, Waterhouse, RM, Abai, MR, Aganezov, SS, Alekseyev, MA, Allen, JE, Amon, J, Arcà, B, Arensburger, P, Artemov, G, Assour, LA, Basseri, H, Berlin, A, Birren, BW, Blandin, SA, Brockman, AI, Burkot, TR, Burt, A, Chan, CS, Chauve, C, Chiu, JC, Christensen, M, Costantini, C, Davidson, VLM, Deligianni, E, Dottorini, T, Dritsou, V, Gabriel, SB, Guelbeogo, WM, Hall, AB, Han, MV, Hlaing, T, Hughes, DST, Jenkins, AM, Jiang, X, Jungreis, I, Kakani, EG, Kamali, M, Kemppainen, P, Kennedy, RC, Kirmitzoglou, IK, Koekemoer, LL, Laban, N, Langridge, N, Lawniczak, MKN, Lirakis, M, Lobo, NF, Lowy, E, MacCallum, RM, Mao, C, Maslen, G, Mbogo, C, McCarthy, J, Michel, K, Mitchell, SN, Moore, W, Murphy, KA, Naumenko, AN, Nolan, T, Novoa, EM, O'Loughlin, S, Oringanje, C, Oshaghi, MA, Pakpour, N, Papathanos, PA, Peery, AN, Povelones, M, Prakash, A, Price, DP, Rajaraman, A, Reimer, LJ, Rinker, DC, Rokas, A, Russell, TL, Sagnon, N'F, Sharakhova, MV, Shea, T, Simão, FA, Simard, F, Slotman, MA, Somboon, P, Stegniy, V, Struchiner, CJ, Thomas, GWC, Tojo, M, Topalis, P, Tubio, JMC, Unger, MF, Vontas, J, Walton, C, Wilding, CS, Willis, JH, Wu, Y-C, Yan, G, Zdobnov, EM, Zhou, X, Catteruccia, F, Christophides, GK, Collins, FH, Cornman, RS, Crisanti, A, Donnelly, MJ, Emrich, SJ, Fontaine, MC, Gelbart, W, Hahn, MW, Hansen, IA, Howell, PI, Kafatos, FC, Kellis, M, Lawson, D, Louis, C, Luckhart, S, Muskavitch, MAT, Ribeiro, JM, Riehle, MA, Sharakhov, IV, Tu, Z, Zwiebel, LJ, Besansky, NJ
JournalScience
Volume347
Issue6217
Pages1258522
Date Published2015 Jan 02
ISSN1095-9203
KeywordsAnimals, Anopheles, Base Sequence, Chromosomes, Insect, Drosophila, Evolution, Molecular, Genome, Insect, Humans, Insect Vectors, Malaria, Molecular Sequence Data, Phylogeny, Sequence Alignment
Abstract

Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.

URLhttp://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=25554792
DOI10.1126/science.1258522
Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/25554792?dopt=Abstract

Alternate JournalScience
PubMed ID25554792
PubMed Central IDPMC4380271
Grant ListR01 AI080799 / AI / NIAID NIH HHS / United States
R01 AI050243 / AI / NIAID NIH HHS / United States
U54 HG003067 / HG / NHGRI NIH HHS / United States
R01 AI095842 / AI / NIAID NIH HHS / United States
G1100339 / / Medical Research Council / United Kingdom
R21 AI101459 / AI / NIAID NIH HHS / United States
U41 HG007234 / HG / NHGRI NIH HHS / United States
R01 AI073745 / AI / NIAID NIH HHS / United States
SC1 AI109055 / AI / NIAID NIH HHS / United States
R01 AI063508 / AI / NIAID NIH HHS / United States
R56 AI107263 / AI / NIAID NIH HHS / United States
R01 AI076584 / AI / NIAID NIH HHS / United States
092654 / / Wellcome Trust / United Kingdom
U19 AI089686 / AI / NIAID NIH HHS / United States
U19 AI110818 / AI / NIAID NIH HHS / United States
R01 AI104956 / AI / NIAID NIH HHS / United States