Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
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Abstract | Insulin sensitivity, insulin secretion, insulin clearance, and glucose effectiveness exhibit strong genetic components, although few studies have examined their genetic architecture or influence on type 2 diabetes (T2D) risk. We hypothesized that loci affecting variation in these quantitative traits influence T2D. We completed a multicohort genome-wide association study to search for loci influencing T2D-related quantitative traits in 4,176 Mexican Americans. Quantitative traits were measured by the frequently sampled intravenous glucose tolerance test (four cohorts) or euglycemic clamp (three cohorts), and random-effects models were used to test the association between loci and quantitative traits, adjusting for age, sex, and admixture proportions (Discovery). Analysis revealed a significant (P |
Year of Publication | 2015
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Journal | Diabetes
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Volume | 64
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Issue | 5
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Pages | 1853-66
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Date Published | 2015 May
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ISSN | 1939-327X
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URL | |
DOI | 10.2337/db14-0732
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PubMed ID | 25524916
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PubMed Central ID | PMC4407862
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Grant list | U01 DK085501 / DK / NIDDK NIH HHS / United States
UL1 TR000430 / TR / NCATS NIH HHS / United States
P30 EY001792 / EY / NEI NIH HHS / United States
R01 DK085175 / DK / NIDDK NIH HHS / United States
N01-HC-95162 / HC / NHLBI NIH HHS / United States
N01HC95160 / HL / NHLBI NIH HHS / United States
R01-HL-071252 / HL / NHLBI NIH HHS / United States
R01 HL071251 / HL / NHLBI NIH HHS / United States
HL-060944 / HL / NHLBI NIH HHS / United States
R01-HL-071258 / HL / NHLBI NIH HHS / United States
HL-102830 / HL / NHLBI NIH HHS / United States
R01 HL071259 / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
UL1-RR-025005 / RR / NCRR NIH HHS / United States
R01 DK061628 / DK / NIDDK NIH HHS / United States
HL-055798 / HL / NHLBI NIH HHS / United States
N01HC95163 / HL / NHLBI NIH HHS / United States
R01 HL071252 / HL / NHLBI NIH HHS / United States
HL-047890 / HL / NHLBI NIH HHS / United States
N01-HC-95163 / HC / NHLBI NIH HHS / United States
R01-HL-071250 / HL / NHLBI NIH HHS / United States
TL1 TR000432 / TR / NCATS NIH HHS / United States
N01-HC-95168 / HC / NHLBI NIH HHS / United States
N01HC95169 / HL / NHLBI NIH HHS / United States
HL-061019 / HL / NHLBI NIH HHS / United States
R01-HL-025005 / HL / NHLBI NIH HHS / United States
R01 HL071250 / HL / NHLBI NIH HHS / United States
HL-047889 / HL / NHLBI NIH HHS / United States
U10-EY-022651 / EY / NEI NIH HHS / United States
N01-HC-95159 / HC / NHLBI NIH HHS / United States
R01 HL088457 / HL / NHLBI NIH HHS / United States
N01-HC-95165 / HC / NHLBI NIH HHS / United States
N01HC95164 / HL / NHLBI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
R01-HL-071251 / HL / NHLBI NIH HHS / United States
UL1-TR-000124 / TR / NCATS NIH HHS / United States
HL-060919 / HL / NHLBI NIH HHS / United States
R01 HL060944 / HL / NHLBI NIH HHS / United States
N01HC95162 / HL / NHLBI NIH HHS / United States
N01HC95168 / HL / NHLBI NIH HHS / United States
R01 EY022651 / EY / NEI NIH HHS / United States
R01 HL102830 / HL / NHLBI NIH HHS / United States
R01 DK073541 / DK / NIDDK NIH HHS / United States
U01 HL047902 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
R01 HL071051 / HL / NHLBI NIH HHS / United States
DK-020595 / DK / NIDDK NIH HHS / United States
HL-088457 / HL / NHLBI NIH HHS / United States
R01-HL-071259 / HL / NHLBI NIH HHS / United States
N01-HC-95169 / HC / NHLBI NIH HHS / United States
R01 HL061019 / HL / NHLBI NIH HHS / United States
N01-HC-95164 / HC / NHLBI NIH HHS / United States
N01HC95165 / HL / NHLBI NIH HHS / United States
N01HC95159 / HL / NHLBI NIH HHS / United States
R01-HL-071205 / HL / NHLBI NIH HHS / United States
UL1-TR-000040 / TR / NCATS NIH HHS / United States
N01HC95161 / HL / NHLBI NIH HHS / United States
DK-073541 / DK / NIDDK NIH HHS / United States
N01-HC-95160 / HC / NHLBI NIH HHS / United States
U10-EY-001792 / EY / NEI NIH HHS / United States
DK-061628 / DK / NIDDK NIH HHS / United States
DK-079888 / DK / NIDDK NIH HHS / United States
HL-0697974 / HL / NHLBI NIH HHS / United States
P01 HL055798 / HL / NHLBI NIH HHS / United States
N01HC95167 / HL / NHLBI NIH HHS / United States
R01 HL060919 / HL / NHLBI NIH HHS / United States
R01 HL071205 / HL / NHLBI NIH HHS / United States
N01-HC-95161 / HC / NHLBI NIH HHS / United States
UL1 TR000040 / TR / NCATS NIH HHS / United States
R01-HL-071051 / HL / NHLBI NIH HHS / United States
N01HC95166 / HL / NHLBI NIH HHS / United States
N02-HL-64278 / HL / NHLBI NIH HHS / United States
DK-063491 / DK / NIDDK NIH HHS / United States
HL-047887 / HL / NHLBI NIH HHS / United States
N01-HC-95166 / HC / NHLBI NIH HHS / United States
DK-085501 / DK / NIDDK NIH HHS / United States
R01 DK079888 / DK / NIDDK NIH HHS / United States
U10 EY011753 / EY / NEI NIH HHS / United States
R01 HL071258 / HL / NHLBI NIH HHS / United States
U10-EY-011753 / EY / NEI NIH HHS / United States
P30 DK020595 / DK / NIDDK NIH HHS / United States
P60 DK020595 / DK / NIDDK NIH HHS / United States
N01-HC-95167 / HC / NHLBI NIH HHS / United States
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