Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.

Diabetes
Authors
Keywords
Abstract

Insulin sensitivity, insulin secretion, insulin clearance, and glucose effectiveness exhibit strong genetic components, although few studies have examined their genetic architecture or influence on type 2 diabetes (T2D) risk. We hypothesized that loci affecting variation in these quantitative traits influence T2D. We completed a multicohort genome-wide association study to search for loci influencing T2D-related quantitative traits in 4,176 Mexican Americans. Quantitative traits were measured by the frequently sampled intravenous glucose tolerance test (four cohorts) or euglycemic clamp (three cohorts), and random-effects models were used to test the association between loci and quantitative traits, adjusting for age, sex, and admixture proportions (Discovery). Analysis revealed a significant (P

Year of Publication
2015
Journal
Diabetes
Volume
64
Issue
5
Pages
1853-66
Date Published
2015 May
ISSN
1939-327X
URL
DOI
10.2337/db14-0732
PubMed ID
25524916
PubMed Central ID
PMC4407862
Links
Grant list
U01 DK085501 / DK / NIDDK NIH HHS / United States
UL1 TR000430 / TR / NCATS NIH HHS / United States
P30 EY001792 / EY / NEI NIH HHS / United States
R01 DK085175 / DK / NIDDK NIH HHS / United States
N01-HC-95162 / HC / NHLBI NIH HHS / United States
N01HC95160 / HL / NHLBI NIH HHS / United States
R01-HL-071252 / HL / NHLBI NIH HHS / United States
R01 HL071251 / HL / NHLBI NIH HHS / United States
HL-060944 / HL / NHLBI NIH HHS / United States
R01-HL-071258 / HL / NHLBI NIH HHS / United States
HL-102830 / HL / NHLBI NIH HHS / United States
R01 HL071259 / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
UL1-RR-025005 / RR / NCRR NIH HHS / United States
R01 DK061628 / DK / NIDDK NIH HHS / United States
HL-055798 / HL / NHLBI NIH HHS / United States
N01HC95163 / HL / NHLBI NIH HHS / United States
R01 HL071252 / HL / NHLBI NIH HHS / United States
HL-047890 / HL / NHLBI NIH HHS / United States
N01-HC-95163 / HC / NHLBI NIH HHS / United States
R01-HL-071250 / HL / NHLBI NIH HHS / United States
TL1 TR000432 / TR / NCATS NIH HHS / United States
N01-HC-95168 / HC / NHLBI NIH HHS / United States
N01HC95169 / HL / NHLBI NIH HHS / United States
HL-061019 / HL / NHLBI NIH HHS / United States
R01-HL-025005 / HL / NHLBI NIH HHS / United States
R01 HL071250 / HL / NHLBI NIH HHS / United States
HL-047889 / HL / NHLBI NIH HHS / United States
U10-EY-022651 / EY / NEI NIH HHS / United States
N01-HC-95159 / HC / NHLBI NIH HHS / United States
R01 HL088457 / HL / NHLBI NIH HHS / United States
N01-HC-95165 / HC / NHLBI NIH HHS / United States
N01HC95164 / HL / NHLBI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
R01-HL-071251 / HL / NHLBI NIH HHS / United States
UL1-TR-000124 / TR / NCATS NIH HHS / United States
HL-060919 / HL / NHLBI NIH HHS / United States
R01 HL060944 / HL / NHLBI NIH HHS / United States
N01HC95162 / HL / NHLBI NIH HHS / United States
N01HC95168 / HL / NHLBI NIH HHS / United States
R01 EY022651 / EY / NEI NIH HHS / United States
R01 HL102830 / HL / NHLBI NIH HHS / United States
R01 DK073541 / DK / NIDDK NIH HHS / United States
U01 HL047902 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
R01 HL071051 / HL / NHLBI NIH HHS / United States
DK-020595 / DK / NIDDK NIH HHS / United States
HL-088457 / HL / NHLBI NIH HHS / United States
R01-HL-071259 / HL / NHLBI NIH HHS / United States
N01-HC-95169 / HC / NHLBI NIH HHS / United States
R01 HL061019 / HL / NHLBI NIH HHS / United States
N01-HC-95164 / HC / NHLBI NIH HHS / United States
N01HC95165 / HL / NHLBI NIH HHS / United States
N01HC95159 / HL / NHLBI NIH HHS / United States
R01-HL-071205 / HL / NHLBI NIH HHS / United States
UL1-TR-000040 / TR / NCATS NIH HHS / United States
N01HC95161 / HL / NHLBI NIH HHS / United States
DK-073541 / DK / NIDDK NIH HHS / United States
N01-HC-95160 / HC / NHLBI NIH HHS / United States
U10-EY-001792 / EY / NEI NIH HHS / United States
DK-061628 / DK / NIDDK NIH HHS / United States
DK-079888 / DK / NIDDK NIH HHS / United States
HL-0697974 / HL / NHLBI NIH HHS / United States
P01 HL055798 / HL / NHLBI NIH HHS / United States
N01HC95167 / HL / NHLBI NIH HHS / United States
R01 HL060919 / HL / NHLBI NIH HHS / United States
R01 HL071205 / HL / NHLBI NIH HHS / United States
N01-HC-95161 / HC / NHLBI NIH HHS / United States
UL1 TR000040 / TR / NCATS NIH HHS / United States
R01-HL-071051 / HL / NHLBI NIH HHS / United States
N01HC95166 / HL / NHLBI NIH HHS / United States
N02-HL-64278 / HL / NHLBI NIH HHS / United States
DK-063491 / DK / NIDDK NIH HHS / United States
HL-047887 / HL / NHLBI NIH HHS / United States
N01-HC-95166 / HC / NHLBI NIH HHS / United States
DK-085501 / DK / NIDDK NIH HHS / United States
R01 DK079888 / DK / NIDDK NIH HHS / United States
U10 EY011753 / EY / NEI NIH HHS / United States
R01 HL071258 / HL / NHLBI NIH HHS / United States
U10-EY-011753 / EY / NEI NIH HHS / United States
P30 DK020595 / DK / NIDDK NIH HHS / United States
P60 DK020595 / DK / NIDDK NIH HHS / United States
N01-HC-95167 / HC / NHLBI NIH HHS / United States