The PD-1 Pathway Regulates Development and Function of Memory CD8 T Cells following Respiratory Viral Infection.
Authors | |
Abstract | The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in the PD-1 pathway exhibit impaired CD8 T cell memory following acute influenza infection, including reduced virus-specific CD8 T cell numbers and compromised recall responses. PD-1 blockade during priming leads to similar differences early post-infection but without the defect in memory formation, suggesting that timing and/or duration of PD-1 blockade could be tailored to modulate host responses. Our studies reveal a role for PD-1 as an integrator of CD8 T cell signals that promotes CD8 T cell memory formation and suggest PD-1 continues to fine-tune CD8 T cells after they migrate into non-lymphoid tissues. These findings have important implications for PD-1-based immunotherapy, in which PD-1 inhibition may influence memory responses in patients. |
Year of Publication | 2020
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Journal | Cell Rep
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Volume | 31
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Issue | 13
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Pages | 107827
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Date Published | 2020 Jun 30
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ISSN | 2211-1247
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DOI | 10.1016/j.celrep.2020.107827
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PubMed ID | 32610128
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Links | |
Grant list | R01 CA229851 / CA / NCI NIH HHS / United States
U19 AI082630 / AI / NIAID NIH HHS / United States
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