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Cell Rep DOI:10.1016/j.celrep.2020.107827

The PD-1 Pathway Regulates Development and Function of Memory CD8 T Cells following Respiratory Viral Infection.

Publication TypeJournal Article
Year of Publication2020
AuthorsPauken, KE, Godec, J, Odorizzi, PM, Brown, KE, Yates, KB, Ngiow, SFoong, Burke, KP, Maleri, S, Grande, SM, Francisco, LM, Ali, M-A, Imam, S, Freeman, GJ, W Haining, N, E Wherry, J, Sharpe, AH
JournalCell Rep
Date Published2020 Jun 30

The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in the PD-1 pathway exhibit impaired CD8 T cell memory following acute influenza infection, including reduced virus-specific CD8 T cell numbers and compromised recall responses. PD-1 blockade during priming leads to similar differences early post-infection but without the defect in memory formation, suggesting that timing and/or duration of PD-1 blockade could be tailored to modulate host responses. Our studies reveal a role for PD-1 as an integrator of CD8 T cell signals that promotes CD8 T cell memory formation and suggest PD-1 continues to fine-tune CD8 T cells after they migrate into non-lymphoid tissues. These findings have important implications for PD-1-based immunotherapy, in which PD-1 inhibition may influence memory responses in patients.


Alternate JournalCell Rep
PubMed ID32610128
Grant ListR01 CA229851 / CA / NCI NIH HHS / United States
U19 AI082630 / AI / NIAID NIH HHS / United States