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Blood Adv DOI:10.1182/bloodadvances.2020001502

Search for multiple myeloma risk factors using Mendelian randomization.

Publication TypeJournal Article
Year of Publication2020
AuthorsWent, M, Cornish, AJ, Law, PJ, Kinnersley, B, van Duin, M, Weinhold, N, Försti, A, Hansson, M, Sonneveld, P, Goldschmidt, H, Morgan, GJ, Hemminki, K, Nilsson, B, Kaiser, M, Houlston, RS
JournalBlood Adv
Date Published2020 May 26

The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian randomization (MR) phenome-wide association study (PheWAS) to search for factors influencing MM risk. We performed an MR-PheWAS analyzing 249 phenotypes, proxied by 10 225 genetic variants, and summary genetic data from a GWAS of 7717 MM cases and 29 304 controls. Odds ratios (ORs) per 1 standard deviation increase in each phenotype were estimated under an inverse variance weighted random effects model. A Bonferroni-corrected threshold of P = 2 × 10-4 was considered significant, whereas P


Alternate JournalBlood Adv
PubMed ID32433745